Acetic acid (2R,3R,4S,5S)-4-acetoxy-2-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-benzoylsulfanylmethyl-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: Acetic acid (2R,3R,4S,5S)-4-acetoxy-2-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-benzoylsulfanylmethyl-tetrahydro-furan-3-yl ester
• CAS No.: 128060-33-3
• Molecular Formula: C₂₇H₂₄N₂O₉S
• Molecular Weight: 552.562

Synonyms:

Chemical Property of Acetic acid (2R,3R,4S,5S)-4-acetoxy-2-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-benzoylsulfanylmethyl-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of Acetic acid (2R,3R,4S,5S)-4-acetoxy-2-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-benzoylsulfanylmethyl-tetrahydro-furan-3-yl ester

There total 6 articles about Acetic acid (2R,3R,4S,5S)-4-acetoxy-2-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-benzoylsulfanylmethyl-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

C70H57ClN7O17PS (128060-30-0,128112-17-4) + tetra-n-butylammoniumfluoride trihydrate (22206-57-1,153005-55-1) → 6-N-benzoyl-2'-O-pixyl-5'-O-toluoyladenosine (121512-96-7) + 6-N-benzoyl-2'-O-pixyl-5'-O-toluoyladenosine-3'-phosphoromonofluoridate n-tetrabutylammonium salt (128060-37-7) + Acetic acid (2R,3R,4S,5S)-4-acetoxy-5-benzoylsulfanylmethyl-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (128060-34-4) + Acetic acid (2R,3R,4S,5S)-4-acetoxy-2-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-benzoylsulfanylmethyl-tetrahydro-furan-3-yl ester (128060-33-3)

Guidance literature:

In tetrahydrofuran; pyridine; water; at 20 ℃; for 1h; Further byproducts given;

DOI:10.1016/S0040-4020(01)89215-2

Reference yield: 74.0%

C70H57ClN7O17PS (128060-30-0,128112-17-4) + tetra-n-butylammoniumfluoride trihydrate (22206-57-1,153005-55-1) → 6-N-benzoyl-2'-O-pixyl-5'-O-toluoyladenosine-3'-phosphoromonofluoridate n-tetrabutylammonium salt (128060-37-7) + Acetic acid (2R,3R,4S,5S)-4-acetoxy-2-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-benzoylsulfanylmethyl-tetrahydro-furan-3-yl ester (128060-33-3) + Acetic acid (2R,3R,4S,5S)-4-acetoxy-2-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-[(2S,3S,4R,5R)-3,4-diacetoxy-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyldisulfanylmethyl]-tetrahydro-furan-3-yl ester (128060-35-5) + Acetic acid (2S,3S,4R,5R)-4-acetoxy-2-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-[(2S,3S,4R,5R)-3,4-diacetoxy-5-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyldisulfanylmethyl]-tetrahydro-furan-3-yl ester (128090-32-4)

Guidance literature:

In tetrahydrofuran; pyridine; water; at 20 ℃; for 1h; Further byproducts given;

DOI:10.1016/S0040-4020(01)89215-2

Reference yield: 30.0%

tetra-n-butylammoniumfluoride trihydrate (22206-57-1,153005-55-1) + O-(2-chlorophenyl)-O-ethyl-S-(5'-deoxy-3-N-benzoyl-2',3'-di-O-acetyl-5'-uridyl)thiophosphate (128060-44-6,128060-65-1) → Acetic acid (2R,3R,4S,5S)-4-acetoxy-5-benzoylsulfanylmethyl-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (128060-34-4) + Acetic acid (2R,3R,4S,5S)-4-acetoxy-2-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-benzoylsulfanylmethyl-tetrahydro-furan-3-yl ester (128060-33-3) + C16H36N(1+)*C2H5FO3P(1-) (128060-48-0) + Acetic acid (2S,3S,4R,5R)-4-acetoxy-2-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-[(2S,3S,4R,5R)-3,4-diacetoxy-5-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyldisulfanylmethyl]-tetrahydro-furan-3-yl ester (128090-32-4)

Guidance literature:

In tetrahydrofuran; pyridine; water; at 20 ℃; for 1h; Further byproducts given;

DOI:10.1016/S0040-4020(01)89215-2

upstream raw materials:

C₇₀H₅₇ClN₇O₁₇PS

tetra-n-butylammoniumfluoride trihydrate

O-(2-chlorophenyl)-O-ethyl-S-(5'-deoxy-3-N-benzoyl-2',3'-di-O-acetyl-5'-uridyl)thiophosphate

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