Benzene, 1-[(chloromethoxy)methyl]-4-fluoro-

Base Information

Chemical Name:Benzene, 1-[(chloromethoxy)methyl]-4-fluoro-
CAS No.:104620-66-8
Molecular Formula:C8H8ClFO
Molecular Weight:174.602
Hs Code.:
DSSTox Substance ID:DTXSID80475075
Wikidata:Q82305333
Mol file:104620-66-8.mol

Synonyms:104620-66-8;Benzene, 1-[(chloromethoxy)methyl]-4-fluoro-;SCHEMBL1287166;DTXSID80475075;MFCD20622117;SY309294;1-[(CHLOROMETHOXY)METHYL]-4-FLUOROBENZENE

Suppliers and Price of Benzene, 1-[(chloromethoxy)methyl]-4-fluoro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Benzene, 1-[(chloromethoxy)methyl]-4-fluoro-

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:174.0247707
Heavy Atom Count:11
Complexity:102

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1COCCl)F

Technology Process of Benzene, 1-[(chloromethoxy)methyl]-4-fluoro-

There total 4 articles about Benzene, 1-[(chloromethoxy)methyl]-4-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 104620-55-5
1-fluoro-4-[(methoxymethoxy)methyl]benzene

: 104620-66-8
1-(chloromethoxymethyl)-4-fluorobenzene

Guidance literature:: With boron trichloride; In hexane; pentane; 1.) 0 deg C, 15 min, 2.) RT, 2 h;
DOI:10.1021/jo00374a040

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 459-56-3
4-fluorobenzylic alcohol

: 104620-66-8
1-(chloromethoxymethyl)-4-fluorobenzene

Guidance literature:: With chloro-trimethyl-silane; at 20 ℃; for 0.75h; Inert atmosphere;
DOI:10.1021/ml1002162

Reference yield:

: 459-56-3
4-fluorobenzylic alcohol

: 104620-66-8
1-(chloromethoxymethyl)-4-fluorobenzene

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / sodium iodide; sodium hydride / tetrahydrofuran / 0 - 20 °C

2: sulfuryl chloride / CH₂Cl₂ / 20 °C

With sulfuryl dichloride; sodium hydride; sodium iodide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2006.08.028