2,6-dimethyl-4-(4-trifluoromethyl-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

Base Information

Chemical Name:2,6-dimethyl-4-(4-trifluoromethyl-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester
CAS No.:108337-81-1
Molecular Formula:C₂₆H₂₈F₃N₃O₄
Molecular Weight:503.521
Hs Code.:

2,6-dimethyl-4-(4-trifluoromethyl-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

Synonyms:

Suppliers and Price of 2,6-dimethyl-4-(4-trifluoromethyl-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,6-dimethyl-4-(4-trifluoromethyl-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,6-dimethyl-4-(4-trifluoromethyl-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

There total 6 articles about 2,6-dimethyl-4-(4-trifluoromethyl-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 54527-65-0
acetoacetic acid [2-(N-methyl-N-benzylamino)-ethyl]-ester

: 132470-83-8
4-(trifluoromethyl)pyridine-2-carbaldehyde

: 14205-39-1
methyl 3-aminocrotonate

: 108337-81-1
2,6-dimethyl-4-(4-trifluoromethyl-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

Guidance literature:: In isopropyl alcohol; at 42 ℃;
DOI:10.1248/cpb.38.2446

Reference yield:

: 81565-18-6
2-chloro-4-trifluoromethyl pyridine

: 108337-81-1
2,6-dimethyl-4-(4-trifluoromethyl-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 2) m-chloroperbenzoic acid / 1) Pd(PPh₃)4 / 1) dioxane, hexane, reflux, 2) CHCl₃, rt

2: 59 percent / Heating

3: 70 percent / aq. NaOH / methanol / 1.5 h / Ambient temperature

4: 25 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H₃PO₄ / 1.5 h / Ambient temperature

5: 54 percent / propan-2-ol / 42 °C

With sodium hydroxide; phosphoric acid; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; isopropyl alcohol;
DOI:10.1248/cpb.38.2446

Reference yield:

: 131747-46-1
(4-trifluoromethyl-pyridin-2-yl)-methanol

: 108337-81-1
2,6-dimethyl-4-(4-trifluoromethyl-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 25 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H₃PO₄ / 1.5 h / Ambient temperature

2: 54 percent / propan-2-ol / 42 °C

With phosphoric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; In isopropyl alcohol;
DOI:10.1248/cpb.38.2446