Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester; compound with triethyl-amine

Base Information

• Chemical Name: Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester; compound with triethyl-amine
• CAS No.: 116113-67-8
• Molecular Formula: C₆H₁₅N*C₄₉H₄₅N₇O₁₁P₂S
• Molecular Weight: 1103.14

Synonyms:

Chemical Property of Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester; compound with triethyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester; compound with triethyl-amine

There total 12 articles about Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexylammonium S,S-diphenyl phosphorodithioate (67941-87-1) → Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester; compound with triethyl-amine (116113-67-8)

Guidance literature:

Multi-step reaction with 4 steps

1: mesitylenedisulfonyl chloride, tetrazole / 0.25 h

2: 55 percent / isoamyl nitrite / acetic anhydride; pyridine; acetic acid / 15 h / Ambient temperature

3: 67 percent / isodurenedisulfonyl chloride / pyridine / 1 h

4: phosphinic acid / pyridine / 0.5 h

With 1H-tetrazole; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; hypophosphorous acid; 2,4,5,6-tetramethylbenzenedisulfonyl dichloride; isopentyl nitrite; In pyridine; acetic anhydride; acetic acid;

DOI:10.1016/S0040-4039(00)96815-1

Reference yield:

Phosphoric acid mono-{(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(bis-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester; compound with triethyl-amine (116113-64-5) → Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester; compound with triethyl-amine (116113-67-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / isodurenedisulfonyl chloride / pyridine / 1 h

2: phosphinic acid / pyridine / 0.5 h

With hypophosphorous acid; 2,4,5,6-tetramethylbenzenedisulfonyl dichloride; In pyridine;

DOI:10.1016/S0040-4039(00)96815-1

Reference yield:

N6-benzoyladenosine 3'-phosphorodianilidate (97997-66-5) → Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2-cyano-ethyl) ester; compound with triethyl-amine (116113-67-8)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / 3 h

2: mesitylenedisulfonyl chloride, tetrazole / 0.25 h

3: 55 percent / isoamyl nitrite / acetic anhydride; pyridine; acetic acid / 15 h / Ambient temperature

4: 67 percent / isodurenedisulfonyl chloride / pyridine / 1 h

5: phosphinic acid / pyridine / 0.5 h

With 1H-tetrazole; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; hypophosphorous acid; 2,4,5,6-tetramethylbenzenedisulfonyl dichloride; isopentyl nitrite; In pyridine; acetic anhydride; acetic acid;

DOI:10.1016/S0040-4039(00)96815-1

upstream raw materials:

triethylamine carbonate

S,S-diphenyl 3'-O-bis(2-cyanoethoxy)phosphinyl-5'-O-(4-methoxytrityl)-6-N-benzoyladenosine 2'-phosphorothioate

triethylamine

cyclohexylammonium S,S-diphenyl phosphorodithioate

Downstream raw materials:

C₈₉H₇₇N₁₃O₁₉P₂S

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