Phosphoric acid mono-{(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(bis-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester; compound with triethyl-amine

Base Information

Chemical Name:Phosphoric acid mono-{(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(bis-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester; compound with triethyl-amine
CAS No.:116113-64-5
Molecular Formula:C₆H₁₅N*C₄₉H₄₃N₅O₁₀P₂S₂
Molecular Weight:1089.18
Hs Code.:

Phosphoric acid mono-{(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(bis-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester; compound with triethyl-amine

Synonyms:Phosphoric acid mono-{(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(bis-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester; compound with triethyl-amine

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Chemical Property of Phosphoric acid mono-{(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(bis-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester; compound with triethyl-amine

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Technology Process of Phosphoric acid mono-{(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(bis-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester; compound with triethyl-amine

There total 10 articles about Phosphoric acid mono-{(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(bis-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 116113-62-3
S,S-diphenyl 3'-O-dianilinophosphinyl-5'-O-(4-methoxytrityl)-6-N-benzoyladenosine 2'-phosphorothioate

: 116113-64-5
Phosphoric acid mono-{(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(bis-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester; compound with triethyl-amine

Guidance literature:: With isopentyl nitrite; In pyridine; acetic anhydride; acetic acid; for 15h; Ambient temperature;
DOI:10.1016/S0040-4039(00)96815-1

Reference yield:

: 67941-87-1
cyclohexylammonium S,S-diphenyl phosphorodithioate

: 116113-64-5
Phosphoric acid mono-{(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(bis-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester; compound with triethyl-amine

Guidance literature:: Multi-step reaction with 2 steps

1: mesitylenedisulfonyl chloride, tetrazole / 0.25 h

2: 55 percent / isoamyl nitrite / acetic anhydride; pyridine; acetic acid / 15 h / Ambient temperature

With 1H-tetrazole; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; isopentyl nitrite; In pyridine; acetic anhydride; acetic acid;
DOI:10.1016/S0040-4039(00)96815-1

Reference yield:

: 97997-66-5
N⁶-benzoyladenosine 3'-phosphorodianilidate

: 116113-64-5
Phosphoric acid mono-{(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(bis-phenylsulfanyl-phosphoryloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester; compound with triethyl-amine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 3 h

2: mesitylenedisulfonyl chloride, tetrazole / 0.25 h

3: 55 percent / isoamyl nitrite / acetic anhydride; pyridine; acetic acid / 15 h / Ambient temperature

With 1H-tetrazole; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; isopentyl nitrite; In pyridine; acetic anhydride; acetic acid;
DOI:10.1016/S0040-4039(00)96815-1