2-(3-Allyloxycarbonylamino-6,7-bis-benzyloxy-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid tert-butyl ester

Base Information

Chemical Name:2-(3-Allyloxycarbonylamino-6,7-bis-benzyloxy-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid tert-butyl ester
CAS No.:128217-89-0
Molecular Formula:C₄₃H₄₃N₃O₉
Molecular Weight:745.829
Hs Code.:

2-(3-Allyloxycarbonylamino-6,7-bis-benzyloxy-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid tert-butyl ester

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Chemical Property of 2-(3-Allyloxycarbonylamino-6,7-bis-benzyloxy-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid tert-butyl ester

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Technology Process of 2-(3-Allyloxycarbonylamino-6,7-bis-benzyloxy-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid tert-butyl ester

There total 20 articles about 2-(3-Allyloxycarbonylamino-6,7-bis-benzyloxy-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22509-74-6
N-ethoxycarbonylphthalimide

: 128217-89-0,128217-90-3
2-(3-Allyloxycarbonylamino-6,7-bis-benzyloxy-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / Na₂CO₃ / H₂O / 5 h / Ambient temperature

2: 96 percent / bromine, red phosphorous / CCl₄ / Heating; 6-8 h

3: 73 percent / HClO₄ / dioxane / 48 h / Ambient temperature

4: 1.) NaH / 1.) THF, 30 min, 2.) reflux, 72 h

With phosphorus; perchloric acid; bromine; sodium hydride; sodium carbonate; In 1,4-dioxane; tetrachloromethane; water;
DOI:10.1021/jo00301a008

Reference yield:

: 3130-75-4
4-phthalimidobutyric acid

: 128217-89-0,128217-90-3
2-(3-Allyloxycarbonylamino-6,7-bis-benzyloxy-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / bromine, red phosphorous / CCl₄ / Heating; 6-8 h

2: 73 percent / HClO₄ / dioxane / 48 h / Ambient temperature

3: 1.) NaH / 1.) THF, 30 min, 2.) reflux, 72 h

With phosphorus; perchloric acid; bromine; sodium hydride; In 1,4-dioxane; tetrachloromethane;
DOI:10.1021/jo00301a008

Reference yield:

: 35197-64-9
2-bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid

: 128217-89-0,128217-90-3
2-(3-Allyloxycarbonylamino-6,7-bis-benzyloxy-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / HClO₄ / dioxane / 48 h / Ambient temperature

2: 1.) NaH / 1.) THF, 30 min, 2.) reflux, 72 h

With perchloric acid; sodium hydride; In 1,4-dioxane;
DOI:10.1021/jo00301a008