Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine

Base Information

• Chemical Name: Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine
• CAS No.: 110808-24-7
• Molecular Formula: C₆H₁₅N*C₄₀H₄₁ClN₃O₁₀P
• Molecular Weight: 891.398
• Mol file: 110808-24-7.mol

Synonyms:

Chemical Property of Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine

There total 4 articles about Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)isobutyramide (100898-62-2) → Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine (110808-24-7)

Guidance literature:

With pyridine; In acetonitrile;

DOI:10.1016/S0040-4039(00)95646-6

Reference yield:

N4-isobutyryll-2'-deoxycytidine (110522-75-3) → Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine (110808-24-7)

Guidance literature:

Multi-step reaction with 2 steps

2: pyridine / acetonitrile

With pyridine; In acetonitrile;

DOI:10.1016/S0040-4039(00)95646-6

Reference yield:

Isobutyric acid (2R,3S,5R)-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-2-isobutyryloxymethyl-tetrahydro-furan-3-yl ester (110522-80-0) → Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine (110808-24-7)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine, water, pyridine

3: pyridine / acetonitrile

With pyridine; water; triethylamine; In acetonitrile;

DOI:10.1016/S0040-4039(00)95646-6

upstream raw materials:

N-(1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)isobutyramide

N⁴-isobutyryll-2'-deoxycytidine

Isobutyric acid (2R,3S,5R)-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-2-isobutyryloxymethyl-tetrahydro-furan-3-yl ester

2'-Deoxycytidine