100898-62-2

Basic information

• Product Name: 5'-O-(4,4'-DIMETHOXYTRITYL)-N4-ISOBUTYRYL-2'-DEOXYCYTIDINE
• Synonyms: DMT-NIBU-DC;5'-O-(4,4'-DIMETHOXYTRITYL)-N4-ISOBUTYRYL-2'-DEOXYCYTIDINE;N4-(ISOBUTYRYL)-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYCYTIDINE;5'-O-(Dimethoxytrityl)-N-isobutyryl-2'-deoxycytidine;Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-methyl-1-oxopropyl)-
• CAS NO: 100898-62-2
• Molecular Formula: C₃₄H₃₇N₃O₇
• Molecular Weight: 599.67
• Mol File: 100898-62-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• Storage Temp.: Store at 2-8°C
• PKA: 10.03±0.20(Predicted)
• CAS DataBase Reference: 5'-O-(4,4'-DIMETHOXYTRITYL)-N4-ISOBUTYRYL-2'-DEOXYCYTIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4'-DIMETHOXYTRITYL)-N4-ISOBUTYRYL-2'-DEOXYCYTIDINE(100898-62-2)
• EPA Substance Registry System: 5'-O-(4,4'-DIMETHOXYTRITYL)-N4-ISOBUTYRYL-2'-DEOXYCYTIDINE(100898-62-2)

Safety Data

• Hazardous Substances Data: 100898-62-2(Hazardous Substances Data)

Usage

General Description

5'-O-(4,4'-dimethoxytrityl)-N4-isobutyryl-2'-deoxycytidine is a complex chemical compound that consists of a cytidine molecule modified with the addition of a 5'-O-(4,4'-dimethoxytrityl) group and a N4-isobutyryl group. 5'-O-(4,4'-DIMETHOXYTRITYL)-N4-ISOBUTYRYL-2'-DEOXYCYTIDINE is used in biochemical research and pharmaceutical development, specifically in the synthesis of nucleosides and nucleotides. The 5'-O-(4,4'-dimethoxytrityl) group serves as a protecting group for the 5'-hydroxyl group of the cytidine molecule, while the N4-isobutyryl group is a modification to the nitrogen atom at position 4 of the cytidine base. This modified cytidine molecule can be used as a building block for the synthesis of nucleic acid analogs and other biologically active compounds.

Upstream product

• 110522-75-3 N⁴-isobutyryll-2'-deoxycytidine 
• 951-77-9 2'-Deoxycytidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 110522-80-0 Isobutyric acid (2R,3S,5R)-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-2-isobutyryloxymethyl-tetrahydro-furan-3-yl ester 

Downstream Products

• 128192-22-3 5'-O-(4,4'-Dimethoxytrityl)-N⁴-isobutyryl-2'-deoxycytidine-3'-(N,N-diisopropyl)methylphosphonamidite 
• 110522-84-4 N⁴-isobutyryl-2'-deoxycytidine-3'-diisopropylaminocyanoethyl phosphoramidite 
• 110808-24-7 Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-isobutyrylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine 

Relevant articles and documents

FAST OLIGONUCLEOTIDE DEPROTECTION. PHOSPHORAMIDITE CHEMISTRY FOR DNA SYNTHESIS

A new set of base protecting groups for cyanoethylphosphoramidite nucleosides has been developed which decreases the post-synthesis time requirements.The traditional purine amide protecting groups, which require 8 - 16 hours at 55 deg C for deprotection in ammonia, have been replaced with the dimethylformamidine group.Oligonucleotides made with the new reagents require only 1 hour at 55 deg C or 8 hours at room temperature for complete deprotection.Dialkylformamidine phosphoramidites exhibit enhanced resistance to depurination compared to the traditional, or even the phenoxyacetyl, phosphoramidites.