100898-62-2 Usage
Uses
Used in Biochemical Research:
5'-O-(4,4'-DIMETHOXYTRITYL)-N4-ISOBUTYRYL-2'-DEOXYCYTIDINE is used as a research compound for studying the structure and function of nucleic acids and their analogs. The 5'-O-(4,4'-dimethoxytrityl) group serves as a protecting group for the 5'-hydroxyl group of the cytidine molecule, allowing for controlled synthesis and modification of nucleic acid structures.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 5'-O-(4,4'-DIMETHOXYTRITYL)-N4-ISOBUTYRYL-2'-DEOXYCYTIDINE is used as a key intermediate in the synthesis of nucleosides and nucleotides, which are essential components of nucleic acids. The N4-isobutyryl group modification to the nitrogen atom at position 4 of the cytidine base enables the development of novel nucleic acid analogs with potential therapeutic applications.
Used in Synthesis of Biologically Active Compounds:
5'-O-(4,4'-DIMETHOXYTRITYL)-N4-ISOBUTYRYL-2'-DEOXYCYTIDINE is utilized as a building block for the synthesis of various biologically active compounds, such as antiviral agents, antimicrobial agents, and other therapeutic molecules. The unique structural features of 5'-O-(4,4'-DIMETHOXYTRITYL)-N4-ISOBUTYRYL-2'-DEOXYCYTIDINE allow for the creation of new molecules with enhanced biological activity and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 100898-62-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,8,9 and 8 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 100898-62:
(8*1)+(7*0)+(6*0)+(5*8)+(4*9)+(3*8)+(2*6)+(1*2)=122
122 % 10 = 2
So 100898-62-2 is a valid CAS Registry Number.
100898-62-2Relevant academic research and scientific papers
FAST OLIGONUCLEOTIDE DEPROTECTION. PHOSPHORAMIDITE CHEMISTRY FOR DNA SYNTHESIS
Vu, Huynh,McCollum, Christie,Jacobson, Karen,Theisen, Pete,Vinayak, Ravi,et al.
, p. 7269 - 7272 (2007/10/02)
A new set of base protecting groups for cyanoethylphosphoramidite nucleosides has been developed which decreases the post-synthesis time requirements.The traditional purine amide protecting groups, which require 8 - 16 hours at 55 deg C for deprotection in ammonia, have been replaced with the dimethylformamidine group.Oligonucleotides made with the new reagents require only 1 hour at 55 deg C or 8 hours at room temperature for complete deprotection.Dialkylformamidine phosphoramidites exhibit enhanced resistance to depurination compared to the traditional, or even the phenoxyacetyl, phosphoramidites.
FACILE REMOVAL OF NEW BASE PROTECTING GROUPS USEFUL IN OLIGONUCLEOTIDE SYNTHESIS
Schulhof, J. C.,Molko, D.,Teoule, R.
, p. 51 - 54 (2007/10/02)
New base protecting groups are proposed in place of benzoyl and isobutyryl groups.They are phenoxy acetyl for adenine and guanine and isobutyryl for cytosine.They are cleaved in aqueous ammonia in a shorter time at lower temperature.These easily removable groups are useful in the synthesis of modified oligonucleotides, containing fragile bases.
