(R)-<(1-Methylethoxy)carbonyl>phenylmethyl (2'S,3R)-2-(3,4-Dimethoxyphenyl)-1'-(4-toluenesulfonyl)-spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate

Base Information

Chemical Name:(R)-<(1-Methylethoxy)carbonyl>phenylmethyl (2'S,3R)-2-(3,4-Dimethoxyphenyl)-1'-(4-toluenesulfonyl)-spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate
CAS No.:129376-71-2
Molecular Formula:C₃₈H₃₈N₂O₈S
Molecular Weight:682.794
Hs Code.:

(R)-<(1-Methylethoxy)carbonyl>phenylmethyl (2'S,3R)-2-(3,4-Dimethoxyphenyl)-1'-(4-toluenesulfonyl)-spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate

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Chemical Property of (R)-<(1-Methylethoxy)carbonyl>phenylmethyl (2'S,3R)-2-(3,4-Dimethoxyphenyl)-1'-(4-toluenesulfonyl)-spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate

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Technology Process of (R)-<(1-Methylethoxy)carbonyl>phenylmethyl (2'S,3R)-2-(3,4-Dimethoxyphenyl)-1'-(4-toluenesulfonyl)-spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate

There total 6 articles about (R)-<(1-Methylethoxy)carbonyl>phenylmethyl (2'S,3R)-2-(3,4-Dimethoxyphenyl)-1'-(4-toluenesulfonyl)-spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 611-71-2
(R)-Mandelic Acid

: 129376-71-2
(R)-<(1-Methylethoxy)carbonyl>phenylmethyl (2'S,3R)-2-(3,4-Dimethoxyphenyl)-1'-(4-toluenesulfonyl)-spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / TsOH / benzene / 7 h / Heating

2: 4-(Dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 5 h / Ambient temperature

3: 1) O₃ / 1) -78 deg C, 2) heating (distillation)

4: molecular sieves / benzene / 30 h / Ambient temperature

5: 2,4,6-Trimethylpyridine / CH₂Cl₂ / 90 h / -80 °C

With 2,4,6-trimethyl-pyridine; dmap; molecular sieve; ozone; triethylamine; toluene-4-sulfonic acid; In dichloromethane; benzene;
DOI:10.1002/hlca.19900730224

Reference yield:

: 129395-22-8
(R)-(2-{(E)-2-[2-(3,4-Dimethoxy-phenyl)-1H-indol-3-yl]-ethylimino}-acetoxy)-phenyl-acetic acid isopropyl ester

: 98-59-9
p-toluenesulfonyl chloride

: 129376-71-2
(R)-<(1-Methylethoxy)carbonyl>phenylmethyl (2'S,3R)-2-(3,4-Dimethoxyphenyl)-1'-(4-toluenesulfonyl)-spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate

Guidance literature:: With 2,4,6-trimethyl-pyridine; In dichloromethane; at -80 ℃; for 90h; Yield given. Further byproducts given;
DOI:10.1002/hlca.19900730224

Reference yield:

: 95426-76-9
2-[2-(3,4-dimethoxyphenyl)-1H-indol-3-yl]-ethylamine

: 129376-71-2
(R)-<(1-Methylethoxy)carbonyl>phenylmethyl (2'S,3R)-2-(3,4-Dimethoxyphenyl)-1'-(4-toluenesulfonyl)-spiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: molecular sieves / benzene / 30 h / Ambient temperature

2: 2,4,6-Trimethylpyridine / CH₂Cl₂ / 90 h / -80 °C

With 2,4,6-trimethyl-pyridine; molecular sieve; In dichloromethane; benzene;
DOI:10.1002/hlca.19900730224