Boc-(R)-MeLeu-(S)-Thr-(3S,4R,5S)-Ist(TBDMS)-(2RS,4S)-Hip-(S)-Leu-(S)-Pro-OBzl

Base Information

• Chemical Name: Boc-(R)-MeLeu-(S)-Thr-(3S,4R,5S)-Ist(TBDMS)-(2RS,4S)-Hip-(S)-Leu-(S)-Pro-OBzl
• CAS No.: 118171-90-7
• Molecular Formula: C₇₅H₁₁₄N₆O₁₇Si
• Molecular Weight: 1399.85
• Mol file: 118171-90-7.mol

Synonyms:

Chemical Property of Boc-(R)-MeLeu-(S)-Thr-(3S,4R,5S)-Ist(TBDMS)-(2RS,4S)-Hip-(S)-Leu-(S)-Pro-OBzl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-(R)-MeLeu-(S)-Thr-(3S,4R,5S)-Ist(TBDMS)-(2RS,4S)-Hip-(S)-Leu-(S)-Pro-OBzl

There total 1 articles about Boc-(R)-MeLeu-(S)-Thr-(3S,4R,5S)-Ist(TBDMS)-(2RS,4S)-Hip-(S)-Leu-(S)-Pro-OBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

H-(2RS,4S)-Hip-(S)-Leu-(S)-Pro-OBzl (118171-82-7,118243-59-7) + Boc-(R)-MeLeu-(S)-Thr[Z-(S)-MeTyr(Me)]-(3S,4R,5S)-Ist(TBDMS)-OH (118171-89-4) → Boc-(R)-MeLeu-(S)-Thr-(3S,4R,5S)-Ist(TBDMS)-(2RS,4S)-Hip-(S)-Leu-(S)-Pro-OBzl (118171-90-7,118243-60-0)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; 0 deg C, 3 h, then r.t., 16 h;

DOI:10.1021/ja00184a041

Reference yield:

Boc-(R)-MeLeu-(S)-Thr-(3S,4R,5S)-Ist(TBDMS)-(2RS,4S)-Hip-(S)-Leu-(S)-Pro-OBzl (118171-90-7,118243-60-0) → C60H102N6O15Si

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 3.5h; Ambient temperature;

DOI:10.1021/ja00184a041

upstream raw materials:

H-(2RS,4S)-Hip-(S)-Leu-(S)-Pro-OBzl

Boc-(R)-MeLeu-(S)-Thr[Z-(S)-MeTyr(Me)]-(3S,4R,5S)-Ist(TBDMS)-OH