(E)-diethyl 4-hydroxybut-2-enylphosphonate

Base Information

• Chemical Name: (E)-diethyl 4-hydroxybut-2-enylphosphonate
• CAS No.: 121077-61-0
• Molecular Formula: C₈H₁₇O₄P
• Molecular Weight: 208.194
• Mol file: 121077-61-0.mol

Synonyms:

Chemical Property of (E)-diethyl 4-hydroxybut-2-enylphosphonate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-diethyl 4-hydroxybut-2-enylphosphonate

There total 1 articles about (E)-diethyl 4-hydroxybut-2-enylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(E)-diethyl (4-acetoxy-2-buten-1-yl)phosphonate (95177-51-8) → (E)-diethyl (4-hydroxy-2-buten-1-yl)phosphonate (121077-61-0)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; for 20h; Heating;

Reference yield: 70.0%

(E)-diethyl (4-hydroxy-2-buten-1-yl)phosphonate (121077-61-0) → (E)-(4-Oxo-2-butenyl)phosphonsaeure-diethylester (110905-37-8)

Guidance literature:

With jones reagent; In acetone; at 0 ℃; for 0.75h;

Reference yield:

(E)-diethyl (4-hydroxy-2-buten-1-yl)phosphonate (121077-61-0) → (2E,4Z)-5-phenylhexa-2,4-dienal (56836-34-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / Jones reagent / acetone / 0.75 h / 0 °C

2: molecular sieves / tetrahydrofuran / Ambient temperature

3: LDA / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) 25 deg C, 111 h

With jones reagent; molecular sieve; lithium diisopropyl amide; In tetrahydrofuran; acetone;

upstream raw materials:

(E)-diethyl (4-acetoxy-2-buten-1-yl)phosphonate

Downstream raw materials:

(E)-(4-Oxo-2-butenyl)phosphonsaeure-diethylester

(2E,4Z)-5-phenylhexa-2,4-dienal

(5-aza-5-cyclohexylpenta-2,4-dienyl)diethoxyphosphin-1-one