Pyridinium, 1-methyl-2-[2-(methylthio)-2-(4-phenyl-1-piperidinyl)ethenyl]-, iodide

Base Information

• Chemical Name: Pyridinium, 1-methyl-2-[2-(methylthio)-2-(4-phenyl-1-piperidinyl)ethenyl]-, iodide
• CAS No.: 104692-93-5
• Molecular Formula: C20H25N2S.I
• Molecular Weight: 452.402
• Mol file: 104692-93-5.mol

Synonyms:

Chemical Property of Pyridinium, 1-methyl-2-[2-(methylthio)-2-(4-phenyl-1-piperidinyl)ethenyl]-, iodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridinium, 1-methyl-2-[2-(methylthio)-2-(4-phenyl-1-piperidinyl)ethenyl]-, iodide

There total 4 articles about Pyridinium, 1-methyl-2-[2-(methylthio)-2-(4-phenyl-1-piperidinyl)ethenyl]-, iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

4-phenylpiperidine (771-99-3) + 1-methyl-2-(2,2-bis(methylthio)vinyl)pyridinium iodide (56185-70-7) → 1-Methyl-2-[(Z)-2-methylsulfanyl-2-(4-phenyl-piperidin-1-yl)-vinyl]-pyridinium; iodide (104692-93-5)

Guidance literature:

In N,N-dimethyl-formamide; at 50 - 70 ℃; for 98.4h;

DOI:10.1021/jm00384a010

Reference yield:

α-picoline (109-06-8) → 1-Methyl-2-[(Z)-2-methylsulfanyl-2-(4-phenyl-piperidin-1-yl)-vinyl]-pyridinium; iodide (104692-93-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi

2: 35 percent / dimethylformamide / 98.4 h / 50 - 70 °C

With n-butyllithium; In N,N-dimethyl-formamide;

DOI:10.1021/jm00384a010

Reference yield:

N-methyl-2-methylpyridinium iodide (872-73-1) → 1-Methyl-2-[(Z)-2-methylsulfanyl-2-(4-phenyl-piperidin-1-yl)-vinyl]-pyridinium; iodide (104692-93-5)

Guidance literature:

Multi-step reaction with 3 steps

1: t-BuOK / 1.) toluene, EtOH, 30 min. 2.) toluene, EtOH, 10 min

2: CH₂Cl₂

3: 35 percent / dimethylformamide / 98.4 h / 50 - 70 °C

With potassium tert-butylate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00384a010

upstream raw materials:

4-phenylpiperidine

1-methyl-2-(2,2-bis(methylthio)vinyl)pyridinium iodide

α-picoline

1-methyl-2-(dithiocarboxymethylene)-1,2-dihydropyridine

Refernces