N-Ethyl-2-{4-[2-(2-fluoro-ethoxy)-pyrimidin-5-ylethynyl]-phenyl}-propionamide

Base Information

Chemical Name:N-Ethyl-2-{4-[2-(2-fluoro-ethoxy)-pyrimidin-5-ylethynyl]-phenyl}-propionamide
CAS No.:1364759-90-9
Molecular Formula:C₁₉H₂₀FN₃O₂
Molecular Weight:341.385
Hs Code.:

Synonyms:

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Chemical Property of N-Ethyl-2-{4-[2-(2-fluoro-ethoxy)-pyrimidin-5-ylethynyl]-phenyl}-propionamide

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Technology Process of N-Ethyl-2-{4-[2-(2-fluoro-ethoxy)-pyrimidin-5-ylethynyl]-phenyl}-propionamide

There total 5 articles about N-Ethyl-2-{4-[2-(2-fluoro-ethoxy)-pyrimidin-5-ylethynyl]-phenyl}-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41073-25-0
2-(4-iodo-phenyl)-propionic acid methyl ester

: 1364759-90-9
N-Ethyl-2-{4-[2-(2-fluoro-ethoxy)-pyrimidin-5-ylethynyl]-phenyl}-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 2 h / 0 - 20 °C

1.2: pH 1

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 h / 0 - 20 °C

3.1: triethylamine; copper(l) iodide / acetonitrile / 2.5 h / 20 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / water; tetrahydrofuran / 0.75 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

6.1: sodium hydride / 1,4-dioxane; mineral oil / 12 h / 20 °C

With copper(l) iodide; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetonitrile; mineral oil;

Reference yield:

: 1364767-24-7
N-ethyl-2-(4-trimethylsilanylethynyl-phenyl)-propionamide

: 1364759-90-9
N-Ethyl-2-{4-[2-(2-fluoro-ethoxy)-pyrimidin-5-ylethynyl]-phenyl}-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / water; tetrahydrofuran / 0.75 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

3: sodium hydride / 1,4-dioxane; mineral oil / 12 h / 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; sodium hydride; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; water; mineral oil;

Reference yield:

: 1364767-30-5
N-ethyl-2-(4-ethynyl-phenyl)-propionamide

: 1364759-90-9
N-Ethyl-2-{4-[2-(2-fluoro-ethoxy)-pyrimidin-5-ylethynyl]-phenyl}-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2: sodium hydride / 1,4-dioxane; mineral oil / 12 h / 20 °C

With copper(l) iodide; sodium hydride; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; mineral oil;