(2S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-[(1R,3aR,4S,7aR)-1-((R)-1,5-dimethyl-hexyl)-4-methoxy-7a-methyl-octahydro-inden-4-ylethynyl]-2-methyl-cyclohexanol

Base Information

Chemical Name:(2S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-[(1R,3aR,4S,7aR)-1-((R)-1,5-dimethyl-hexyl)-4-methoxy-7a-methyl-octahydro-inden-4-ylethynyl]-2-methyl-cyclohexanol
CAS No.:109243-45-0
Molecular Formula:C₃₄H₆₂O₃Si
Molecular Weight:546.95
Hs Code.:

(2S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-[(1R,3aR,4S,7aR)-1-((R)-1,5-dimethyl-hexyl)-4-methoxy-7a-methyl-octahydro-inden-4-ylethynyl]-2-methyl-cyclohexanol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-[(1R,3aR,4S,7aR)-1-((R)-1,5-dimethyl-hexyl)-4-methoxy-7a-methyl-octahydro-inden-4-ylethynyl]-2-methyl-cyclohexanol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (2S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-[(1R,3aR,4S,7aR)-1-((R)-1,5-dimethyl-hexyl)-4-methoxy-7a-methyl-octahydro-inden-4-ylethynyl]-2-methyl-cyclohexanol

There total 15 articles about (2S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-[(1R,3aR,4S,7aR)-1-((R)-1,5-dimethyl-hexyl)-4-methoxy-7a-methyl-octahydro-inden-4-ylethynyl]-2-methyl-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62392-84-1
(+)-(R)-6-methylcyclohex-2-en-1-one

: 109243-45-0,109361-33-3
(2R,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-1-[(1R,3aR,4S,7aR)-1-((R)-1,5-dimethyl-hexyl)-4-methoxy-7a-methyl-octahydro-inden-4-ylethynyl]-2-methyl-cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / DIBAL / hexane; benzene / 0.5 h / 0 °C

2: 55 percent / tert-butyl hydroperoxide, vanadyl acetoacetate / 24 h / Ambient temperature

3: 95 percent / PDC / dimethylformamide / 6 h / 0 °C

4: 50 percent / Al/Hg, NaHCO₃ / ethanol

5: 1.) n-BuLi / 1.) THF, hexane, RT, 5 min, 2.) THF, hexane, RT, 1 h

With tert.-butylhydroperoxide; aluminum amalgam; dipyridinium dichromate; n-butyllithium; vanadyl acetoacetonate; diisobutylaluminium hydride; sodium hydrogencarbonate; In ethanol; hexane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00392a012

Reference yield:

: 109428-38-8
(1R,6R)-6-methylcyclohex-2-en-1-ol

: 109243-45-0,109361-33-3
(2R,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-1-[(1R,3aR,4S,7aR)-1-((R)-1,5-dimethyl-hexyl)-4-methoxy-7a-methyl-octahydro-inden-4-ylethynyl]-2-methyl-cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / tert-butyl hydroperoxide, vanadyl acetoacetate / 24 h / Ambient temperature

2: 95 percent / PDC / dimethylformamide / 6 h / 0 °C

3: 50 percent / Al/Hg, NaHCO₃ / ethanol

4: 1.) n-BuLi / 1.) THF, hexane, RT, 5 min, 2.) THF, hexane, RT, 1 h

With tert.-butylhydroperoxide; aluminum amalgam; dipyridinium dichromate; n-butyllithium; vanadyl acetoacetonate; sodium hydrogencarbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00392a012

Reference yield:

: 67-97-0
vitamin D₃

: 109243-45-0,109361-33-3
(2R,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-1-[(1R,3aR,4S,7aR)-1-((R)-1,5-dimethyl-hexyl)-4-methoxy-7a-methyl-octahydro-inden-4-ylethynyl]-2-methyl-cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) ozone, 2.) Me₂S / 1.) methanol, -78 deg C, 2.) methanol, RT, 8 h

2: ethylmagnesium bromide / tetrahydrofuran / 2 h / Ambient temperature

3: KOH / dimethylsulfoxide / 0.25 h / Ambient temperature

4: 1.) n-BuLi / 1.) THF, hexane, RT, 5 min, 2.) THF, hexane, RT, 1 h

With potassium hydroxide; n-butyllithium; dimethylsulfide; ethylmagnesium bromide; ozone; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/jo00392a012