Technology Process of Methanesulfonic acid 3-[acetyl-(4-tetradecyloxy-benzyl)-amino]-benzyl ester
There total 10 articles about Methanesulfonic acid 3-[acetyl-(4-tetradecyloxy-benzyl)-amino]-benzyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: potassium carbonate / acetone / Heating
2: aq. KOH / methanol
3: oxalyl chloride, DMF / CH2Cl2
4: pyridine / tetrahydrofuran / Ambient temperature
5: 86 percent / LiAlH4 / tetrahydrofuran / 1.) RT, 1 h, 2.) reflux, 7 h
6: pyridine / CH2Cl2 / 1.5 h / Ambient temperature
7: aq. NaOH / ethanol / 0.58 h
8: triethylamine / tetrahydrofuran / 1.5 h
With
pyridine; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; acetone;
DOI:10.1021/jm00104a002
- Guidance literature:
-
Multi-step reaction with 5 steps
1: pyridine / tetrahydrofuran / Ambient temperature
2: 86 percent / LiAlH4 / tetrahydrofuran / 1.) RT, 1 h, 2.) reflux, 7 h
3: pyridine / CH2Cl2 / 1.5 h / Ambient temperature
4: aq. NaOH / ethanol / 0.58 h
5: triethylamine / tetrahydrofuran / 1.5 h
With
pyridine; sodium hydroxide; lithium aluminium tetrahydride; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00104a002
- Guidance literature:
-
Multi-step reaction with 6 steps
1: oxalyl chloride, DMF / CH2Cl2
2: pyridine / tetrahydrofuran / Ambient temperature
3: 86 percent / LiAlH4 / tetrahydrofuran / 1.) RT, 1 h, 2.) reflux, 7 h
4: pyridine / CH2Cl2 / 1.5 h / Ambient temperature
5: aq. NaOH / ethanol / 0.58 h
6: triethylamine / tetrahydrofuran / 1.5 h
With
pyridine; sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00104a002
