(1R,3S)-5-{(Z)-2-[(1R,3aR,7aR)-1-((E)-(1R,4R)-5-Hydroxy-1,4,5-trimethyl-hex-2-enyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]-vinyl}-4-methyl-cyclohex-4-ene-1,3-diol

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Chemical Name:(1R,3S)-5-{(Z)-2-[(1R,3aR,7aR)-1-((E)-(1R,4R)-5-Hydroxy-1,4,5-trimethyl-hex-2-enyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]-vinyl}-4-methyl-cyclohex-4-ene-1,3-diol
CAS No.:125762-66-5
Molecular Formula:C₂₈H₄₄O₃
Molecular Weight:428.656
Hs Code.:

(1R,3S)-5-{(Z)-2-[(1R,3aR,7aR)-1-((E)-(1R,4R)-5-Hydroxy-1,4,5-trimethyl-hex-2-enyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]-vinyl}-4-methyl-cyclohex-4-ene-1,3-diol

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Chemical Property of (1R,3S)-5-{(Z)-2-[(1R,3aR,7aR)-1-((E)-(1R,4R)-5-Hydroxy-1,4,5-trimethyl-hex-2-enyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]-vinyl}-4-methyl-cyclohex-4-ene-1,3-diol

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Technology Process of (1R,3S)-5-{(Z)-2-[(1R,3aR,7aR)-1-((E)-(1R,4R)-5-Hydroxy-1,4,5-trimethyl-hex-2-enyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]-vinyl}-4-methyl-cyclohex-4-ene-1,3-diol

There total 13 articles about (1R,3S)-5-{(Z)-2-[(1R,3aR,7aR)-1-((E)-(1R,4R)-5-Hydroxy-1,4,5-trimethyl-hex-2-enyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]-vinyl}-4-methyl-cyclohex-4-ene-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 125762-64-3
(24R,22E)-5,7,22-ergostatriene-1α,3β,25-triol

: 125762-66-5
(1R,3S)-5-{(Z)-2-[(1R,3aR,7aR)-1-((E)-(1R,4R)-5-Hydroxy-1,4,5-trimethyl-hex-2-enyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]-vinyl}-4-methyl-cyclohex-4-ene-1,3-diol

Guidance literature:: In tetrahydrofuran; diethyl ether; for 0.05h; Irradiation;
DOI:10.1246/bcsj.62.3132

Reference yield:

: 73295-16-6
(R)-2,3-dimethyl-1,3-butanediol

: 125762-66-5
(1R,3S)-5-{(Z)-2-[(1R,3aR,7aR)-1-((E)-(1R,4R)-5-Hydroxy-1,4,5-trimethyl-hex-2-enyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]-vinyl}-4-methyl-cyclohex-4-ene-1,3-diol

Guidance literature:: Multi-step reaction with 9 steps

1: pyridine / Ambient temperature

2: potassium t-butoxide / dimethylformamide / Ambient temperature

3: WO₃, 50percent NaOH, 30percent H₂O₂ / H₂O; ethanol / 0.67 h / 60 - 75 °C

4: 94 percent / PPTS / CH₂Cl₂ / 4 h / Ambient temperature

5: n-butyllithium / hexane; tetrahydrofuran / 1 h / -70 - -60 °C

6: Na₂HPO₄, 5percent sodium amalgam / methanol / 0 deg C, 15 h, then RT, 3 h

7: PPTS / aq. ethanol / 1 h / 50 °C

8: LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

9: 28 percent / diethyl ether; tetrahydrofuran / 0.05 h / Irradiation

With pyridine; sodium hydroxide; disodium hydrogenphosphate; sodium amalgam; lithium aluminium tetrahydride; n-butyllithium; potassium tert-butylate; dihydrogen peroxide; tungsten(VI) oxide; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.62.3132

Reference yield:

: 125315-53-9
22-Oxo-5α,8α-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-23,24-dinor-6-cholene-1α,3β-diyl diacetate

: 125762-66-5
(1R,3S)-5-{(Z)-2-[(1R,3aR,7aR)-1-((E)-(1R,4R)-5-Hydroxy-1,4,5-trimethyl-hex-2-enyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]-vinyl}-4-methyl-cyclohex-4-ene-1,3-diol

Guidance literature:: Multi-step reaction with 5 steps

1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -70 - -60 °C

2: Na₂HPO₄, 5percent sodium amalgam / methanol / 0 deg C, 15 h, then RT, 3 h

3: PPTS / aq. ethanol / 1 h / 50 °C

4: LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

5: 28 percent / diethyl ether; tetrahydrofuran / 0.05 h / Irradiation

With disodium hydrogenphosphate; sodium amalgam; lithium aluminium tetrahydride; n-butyllithium; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane;
DOI:10.1246/bcsj.62.3132