bis-[1,2,4]triazol-1-yl-phosphinothioic acid O-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

Base Information

Chemical Name:bis-[1,2,4]triazol-1-yl-phosphinothioic acid O-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester
CAS No.:220573-11-5
Molecular Formula:C₃₅H₃₅N₈O₇PS
Molecular Weight:742.752
Hs Code.:

bis-[1,2,4]triazol-1-yl-phosphinothioic acid <i>O</i>-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

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Chemical Property of bis-[1,2,4]triazol-1-yl-phosphinothioic acid O-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

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Technology Process of bis-[1,2,4]triazol-1-yl-phosphinothioic acid O-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

There total 1 articles about bis-[1,2,4]triazol-1-yl-phosphinothioic acid O-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 158604-14-9
thiophosphoryl tris(1,2,4-triazolide)

: 220573-11-5
bis-[1,2,4]triazol-1-yl-phosphinothioic acid O-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

Guidance literature:: With pyridine; In tetrahydrofuran; Yield given; Ambient temperature;
DOI:10.1246/cl.1999.39

Reference yield:

: 220573-11-5
bis-[1,2,4]triazol-1-yl-phosphinothioic acid O-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

: C₃₄H₃₅N₃O₉PS^(1-)

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / tetrahydrofuran / Ambient temperature

2: triethylamine, water

With pyridine; water; triethylamine; In tetrahydrofuran;
DOI:10.1246/cl.1999.39

Reference yield:

: 220573-11-5
bis-[1,2,4]triazol-1-yl-phosphinothioic acid O-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

: thiophosphoric acid O-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O'-(2-cyano-ethyl) ester S-(4-nitro-benzyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / tetrahydrofuran / Ambient temperature

2: triethylamine, water

3: 2,6-lutidine / acetonitrile / 4 h / Ambient temperature

With pyridine; 2,6-dimethylpyridine; water; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1246/cl.1999.39