Methanesulfonic acid (1S,2S,3R,4R)-2-(3-hydroxy-benzyl)-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentylmethyl ester

Base Information

• Chemical Name: Methanesulfonic acid (1S,2S,3R,4R)-2-(3-hydroxy-benzyl)-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentylmethyl ester
• CAS No.: 81872-06-2
• Molecular Formula: C₃₂H₅₀O₈S
• Molecular Weight: 594.81

Synonyms:

Chemical Property of Methanesulfonic acid (1S,2S,3R,4R)-2-(3-hydroxy-benzyl)-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (1S,2S,3R,4R)-2-(3-hydroxy-benzyl)-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentylmethyl ester

There total 4 articles about Methanesulfonic acid (1S,2S,3R,4R)-2-(3-hydroxy-benzyl)-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methanesulfonic acid (1S,2S,3R,4R)-2-[3-(tert-butyl-dimethyl-silanyloxy)-benzyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentylmethyl ester (81168-32-3,81203-95-4,81846-02-8,81846-27-7) → Methanesulfonic acid (1S,2S,3R,4R)-2-(3-hydroxy-benzyl)-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentylmethyl ester (81872-06-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)87262-7

Reference yield:

{(1S,2S,3R,4R)-2-[3-(tert-Butyl-dimethyl-silanyloxy)-benzyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentyl}-methanol (81846-26-6) → Methanesulfonic acid (1S,2S,3R,4R)-2-(3-hydroxy-benzyl)-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentylmethyl ester (81872-06-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / triethylamine / CH₂Cl₂

2: tetra-n-butylammonium fluoride / tetrahydrofuran

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(00)87262-7

Reference yield:

tert-Butyl-dimethyl-(3-{(1R,2R,3R)-5-methylene-3-(tetrahydro-pyran-2-yloxy)-2-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentylmethyl}-phenoxy)-silane (81846-25-5) → Methanesulfonic acid (1S,2S,3R,4R)-2-(3-hydroxy-benzyl)-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentylmethyl ester (81872-06-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) 9-borabicyclo<3.3.1>nonane 2) hydrogen peroxide

2: 88 percent / triethylamine / CH₂Cl₂

3: tetra-n-butylammonium fluoride / tetrahydrofuran

With 9-borabicyclo[3.3.1]nonane dimer; tetrabutyl ammonium fluoride; dihydrogen peroxide; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(00)87262-7

upstream raw materials:

Methanesulfonic acid (1S,2S,3R,4R)-2-[3-(tert-butyl-dimethyl-silanyloxy)-benzyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentylmethyl ester

{(1S,2S,3R,4R)-2-[3-(tert-Butyl-dimethyl-silanyloxy)-benzyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentyl}-methanol

tert-Butyl-dimethyl-(3-{(1R,2R,3R)-5-methylene-3-(tetrahydro-pyran-2-yloxy)-2-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentylmethyl}-phenoxy)-silane

(2R,3R,4R)-2-(3-(tert-butyldimethylsilyloxy)benzyl)-4-(tetrahydro-2H-pyran-2-yloxy)-3-((3S,1E)-3-(tetrahydro-2H-pyran-2-yloxy)oct-1-enyl)cyclopentanone

Downstream raw materials:

(1R,2R,3aS,9aS)-2-(Tetrahydro-pyran-2-yloxy)-1-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-ol

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