Cyclopentanone, 2-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]methyl]-4-[(tetrahydro-2 H-pyran-2-yl)oxy]-3-[3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-octenyl]-, [2R-[2a,3b(1E,3S*),4a]]-

Base Information

• Chemical Name: Cyclopentanone, 2-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]methyl]-4-[(tetrahydro-2 H-pyran-2-yl)oxy]-3-[3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-octenyl]-, [2R-[2a,3b(1E,3S*),4a]]-
• CAS No.: 65423-57-6
• Molecular Formula: C36H58O6Si
• Molecular Weight: 614.938
• Mol file: 65423-57-6.mol

Synonyms:Cyclopentanone, 2-[[3-[[(1,1-diMethylethyl)diMethylsilyl]oxy]phenyl]Methyl]-4-[(tetrahydro-2 H-pyran-2-yl)oxy]-3-[3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-octenyl]-, [2R-[2a,3b(1E,3S*),4a]]-;(2R,3R,4R)-2-(3-((tert-Butyldimethylsilyl)oxy)benzyl)-4-((tetrahydro-2H-pyran-2-yl)oxy)-3-((3S,E)

Chemical Property of Cyclopentanone, 2-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]methyl]-4-[(tetrahydro-2 H-pyran-2-yl)oxy]-3-[3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-octenyl]-, [2R-[2a,3b(1E,3S*),4a]]-

Chemical Property:

• PSA: 63.22000
• LogP: 8.77840
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(2R,3R,4R)-2-(3-((tert-Butyldimethylsilyl)oxy)benzyl)-4-((tetrahydro-2H-pyran-2-yl)oxy)-3-((3S,E)-3-((tetrahydro-2H-pyran-2-yl)oxy)oct-1-en-1-yl)cyclopentanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopentanone, 2-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]methyl]-4-[(tetrahydro-2 H-pyran-2-yl)oxy]-3-[3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-octenyl]-, [2R-[2a,3b(1E,3S*),4a]]-

There total 1 articles about Cyclopentanone, 2-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]methyl]-4-[(tetrahydro-2 H-pyran-2-yl)oxy]-3-[3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-octenyl]-, [2R-[2a,3b(1E,3S*),4a]]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(R)-1-(3-(tert-butyldimethylsilyloxy)benzyl)-5-oxo-3-(tetrahydro-2H-pyran-2-yloxy)-cyclopentene (1425937-60-5) + (1E)-iodo-(3S)-(tetrahydro-2H-pyran-2-yloxy)-1-octene (72522-67-9) → (2R,3R,4R)-2-(3-(tert-butyldimethylsilyloxy)benzyl)-4-(tetrahydro-2H-pyran-2-yloxy)-3-((3S,1E)-3-(tetrahydro-2H-pyran-2-yloxy)oct-1-enyl)cyclopentanone (65423-57-6)

Guidance literature:

(1E)-iodo-(3S)-(tetrahydro-2H-pyran-2-yloxy)-1-octene; With 1-pentynyl copper; n-butyllithium; Hexamethylphosphorous triamide; In diethyl ether; hexane; at -70 ℃; for 0.5h;

(R)-1-(3-(tert-butyldimethylsilyloxy)benzyl)-5-oxo-3-(tetrahydro-2H-pyran-2-yloxy)-cyclopentene; In diethyl ether; hexane; at -70 ℃; for 0.5h;

Reference yield:

(2R,3R,4R)-2-(3-(tert-butyldimethylsilyloxy)benzyl)-4-(tetrahydro-2H-pyran-2-yloxy)-3-((3S,1E)-3-(tetrahydro-2H-pyran-2-yloxy)oct-1-enyl)cyclopentanone (65423-57-6) → Methanesulfonic acid (1S,2S,3R,4R)-2-(3-hydroxy-benzyl)-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentylmethyl ester (81872-06-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 2) aluminum amalgam / 1) THF 2) water-acetic acid-THF (1:1:6)

2: 1) 9-borabicyclo<3.3.1>nonane 2) hydrogen peroxide

3: 88 percent / triethylamine / CH₂Cl₂

4: tetra-n-butylammonium fluoride / tetrahydrofuran

With 9-borabicyclo[3.3.1]nonane dimer; aluminium amalgam; tetrabutyl ammonium fluoride; dihydrogen peroxide; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(00)87262-7

Reference yield:

(2R,3R,4R)-2-(3-(tert-butyldimethylsilyloxy)benzyl)-4-(tetrahydro-2H-pyran-2-yloxy)-3-((3S,1E)-3-(tetrahydro-2H-pyran-2-yloxy)oct-1-enyl)cyclopentanone (65423-57-6) → Methanesulfonic acid (1S,2S,3R,4R)-2-[3-(tert-butyl-dimethyl-silanyloxy)-benzyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentylmethyl ester (81168-32-3,81203-95-4,81846-02-8,81846-27-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 2) aluminum amalgam / 1) THF 2) water-acetic acid-THF (1:1:6)

2: 1) 9-borabicyclo<3.3.1>nonane 2) hydrogen peroxide

3: 88 percent / triethylamine / CH₂Cl₂

With 9-borabicyclo[3.3.1]nonane dimer; aluminium amalgam; dihydrogen peroxide; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4039(00)87262-7

upstream raw materials:

(R)-1-(3-(tert-butyldimethylsilyloxy)benzyl)-5-oxo-3-(tetrahydro-2H-pyran-2-yloxy)-cyclopentene

(1E)-iodo-(3S)-(tetrahydro-2H-pyran-2-yloxy)-1-octene

Downstream raw materials:

tert-Butyl-dimethyl-(3-{(1R,2R,3R)-5-methylene-3-(tetrahydro-pyran-2-yloxy)-2-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentylmethyl}-phenoxy)-silane

(1R,2R,3aS,9aS)-2-(Tetrahydro-pyran-2-yloxy)-1-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-ol

(1S,2R,3R,4R)-2-(3-Hydroxy-benzyl)-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentanecarbaldehyde

{(1S,2S,3R,4R)-2-[3-(tert-Butyl-dimethyl-silanyloxy)-benzyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentyl}-methanol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 65423-57-6 Cyclopentanone, 2-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]methyl]-4-[(tetrahydro-2 H-pyran-2-yl)oxy]-3-[3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-octenyl]-, [2R-[2a,3b(1E,3S*),4a]]-

Send

Send

Metric Ton KG G Pound L ML

Send

Send