3-[(2-Ethoxyphenoxy)methyl]-1-(phenylmethyl)piperidine

Base Information

Chemical Name:3-[(2-Ethoxyphenoxy)methyl]-1-(phenylmethyl)piperidine
CAS No.:104778-59-8
Molecular Formula:C21H27NO2
Molecular Weight:325.451
Hs Code.:
DSSTox Substance ID:DTXSID301208260
Mol file:104778-59-8.mol

Synonyms:3-[(2-Ethoxyphenoxy)methyl]-1-(phenylmethyl)piperidine;DTXSID301208260;104778-59-8

Suppliers and Price of 3-[(2-Ethoxyphenoxy)methyl]-1-(phenylmethyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[(2-Ethoxyphenoxy)methyl]-1-(phenylmethyl)piperidine

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:325.204179104
Heavy Atom Count:24
Complexity:343

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC1=CC=CC=C1OCC2CCCN(C2)CC3=CC=CC=C3

Technology Process of 3-[(2-Ethoxyphenoxy)methyl]-1-(phenylmethyl)piperidine

There total 4 articles about 3-[(2-Ethoxyphenoxy)methyl]-1-(phenylmethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 614-18-6
3-pyridinecarboxylic acid ethyl ester

: 104778-59-8
1-benzyl-3-<(2-ethoxyphenoxy)methyl>piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Na 2.) H₂ / 2.) 10percent Pd/C / 1.) EtOH, 2.) EtOH, RT, atm. pressure, 6 h

2: 3.2 g / K₂CO₃ / acetone / 24 h / Ambient temperature

3: 1.4 g / SOCl₂, HCl / CHCl₃ / 1.5 h / Heating

4: ethanol / 30 h / 100 °C

With hydrogenchloride; thionyl chloride; hydrogen; sodium; potassium carbonate; palladium on activated charcoal; In ethanol; chloroform; acetone;
DOI:10.1021/jm00384a040

Reference yield:

: 4606-65-9
3-(hydroxymethy)piperidine

: 104778-59-8
1-benzyl-3-<(2-ethoxyphenoxy)methyl>piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 3.2 g / K₂CO₃ / acetone / 24 h / Ambient temperature

2: 1.4 g / SOCl₂, HCl / CHCl₃ / 1.5 h / Heating

3: ethanol / 30 h / 100 °C

With hydrogenchloride; thionyl chloride; potassium carbonate; In ethanol; chloroform; acetone;
DOI:10.1021/jm00384a040

Reference yield:

: 85387-44-6
1-benzyl-3-(hydroxymethyl)piperidine

: 104778-59-8
1-benzyl-3-<(2-ethoxyphenoxy)methyl>piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.4 g / SOCl₂, HCl / CHCl₃ / 1.5 h / Heating

2: ethanol / 30 h / 100 °C

With hydrogenchloride; thionyl chloride; In ethanol; chloroform;
DOI:10.1021/jm00384a040