N-(3-fluoro-4-((6-methoxy-7-(3-(morpholin-4-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydroquinoline-3-carboxamide

Base Information

Chemical Name:N-(3-fluoro-4-((6-methoxy-7-(3-(morpholin-4-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydroquinoline-3-carboxamide
CAS No.:1394165-61-7
Molecular Formula:C₄₀H₃₄F₄N₄O₆
Molecular Weight:742.727
Hs Code.:

N-(3-fluoro-4-((6-methoxy-7-(3-(morpholin-4-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydroquinoline-3-carboxamide

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Chemical Property of N-(3-fluoro-4-((6-methoxy-7-(3-(morpholin-4-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydroquinoline-3-carboxamide

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Technology Process of N-(3-fluoro-4-((6-methoxy-7-(3-(morpholin-4-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydroquinoline-3-carboxamide

There total 18 articles about N-(3-fluoro-4-((6-methoxy-7-(3-(morpholin-4-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydroquinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 479690-10-3
3-Fluoro-4-{[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy}-aniline

: C₁₇H₉ClF₃NO₂

: 1394165-61-7
N-(3-fluoro-4-((6-methoxy-7-(3-(morpholin-4-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 10h; Cooling with ice;
DOI:10.1002/ardp.201300029

Reference yield:

: C₁₉H₁₅F₄NO₃

: 1394165-61-7
N-(3-fluoro-4-((6-methoxy-7-(3-(morpholin-4-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 50 °C

2: sodium hydroxide / ethanol / 5 h / 20 °C

3: thionyl chloride / toluene / 5 h / 80 °C

4: triethylamine / dichloromethane / 10 h / 20 °C / Cooling with ice

With thionyl chloride; potassium carbonate; triethylamine; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/ardp.201300029

Reference yield:

: 205448-32-4
4-chloro-6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinoline

: 1394165-61-7
N-(3-fluoro-4-((6-methoxy-7-(3-(morpholin-4-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: chlorobenzene / 30 h / 140 °C

2: iron; ammonium chloride / ethanol / 5 h / Reflux

3: triethylamine / dichloromethane / 10 h / 20 °C / Cooling with ice

With iron; ammonium chloride; triethylamine; In ethanol; dichloromethane; chlorobenzene;
DOI:10.1002/ardp.201300029