Technology Process of C16H20(2)HNO7
There total 5 articles about C16H20(2)HNO7 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dipotassium hydrogenphosphate; acetic anhydride / 80 °C / Inert atmosphere
1.2: 80 °C / Inert atmosphere
2.1: sodium hydroxide; water / ethanol / Reflux
3.1: [Rh(NBD)((R)-Prophos)]ClO4; hydrogen / tetrahydrofuran / 16 h / 1500.15 Torr
3.2: Dowex 50 W (100?200 mesh) cation exchange resin
4.1: hydrogen bromide / water / 3 h / Reflux
4.2: 1 h / 0 °C
5.1: pyridine / aq. phosphate buffer / 0.17 h / pH 8.5
5.2: pH 2
With
pyridine; dipotassium hydrogenphosphate; [Rh(NBD)((R)-Prophos)]ClO4; water; hydrogen bromide; hydrogen; acetic anhydride; sodium hydroxide;
In
tetrahydrofuran; aq. phosphate buffer; ethanol; water;
DOI:10.1021/ja403918w
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide; water / ethanol / Reflux
2.1: [Rh(NBD)((R)-Prophos)]ClO4; hydrogen / tetrahydrofuran / 16 h / 1500.15 Torr
2.2: Dowex 50 W (100?200 mesh) cation exchange resin
3.1: hydrogen bromide / water / 3 h / Reflux
3.2: 1 h / 0 °C
4.1: pyridine / aq. phosphate buffer / 0.17 h / pH 8.5
4.2: pH 2
With
pyridine; [Rh(NBD)((R)-Prophos)]ClO4; water; hydrogen bromide; hydrogen; sodium hydroxide;
In
tetrahydrofuran; aq. phosphate buffer; ethanol; water;
DOI:10.1021/ja403918w
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogen bromide / water / 3 h / Reflux
1.2: 1 h / 0 °C
2.1: pyridine / aq. phosphate buffer / 0.17 h / pH 8.5
2.2: pH 2
With
pyridine; hydrogen bromide;
In
aq. phosphate buffer; water;
DOI:10.1021/ja403918w