formic acid 1-benzylcarbamoyl-2-isocyano-propyl ester

Base Information

Chemical Name:formic acid 1-benzylcarbamoyl-2-isocyano-propyl ester
CAS No.:460048-60-6
Molecular Formula:C₁₃H₁₄N₂O₃
Molecular Weight:246.266
Hs Code.:

Synonyms:

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Chemical Property of formic acid 1-benzylcarbamoyl-2-isocyano-propyl ester

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Technology Process of formic acid 1-benzylcarbamoyl-2-isocyano-propyl ester

There total 6 articles about formic acid 1-benzylcarbamoyl-2-isocyano-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32331-52-5
N-benzyl glyoxylic amide

: 460048-60-6
formic acid 1-benzylcarbamoyl-2-isocyano-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 29.0 g / KF/Al₂O₃ / 48 h / 20 °C

2.1: H₂; HCOOH / 10 percent Pd/C; P-2 Ni / methanol / 12 h / 20 °C / 3040 Torr

2.2: Zn; aq. NH₄Cl / methanol / 12 h / 20 °C

3.1: 1.68 g / imidazole; DCC; HCOOH / Et₃N / 48 h / 20 °C

4.1: POCl₃; Et₃N / CH₂Cl₂ / 0.5 h

With 1H-imidazole; aluminum oxide; potassium fluoride; formic acid; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trichlorophosphate; palladium on activated charcoal; triethylamine; In methanol; dichloromethane;
DOI:10.1055/s-2002-31948

Reference yield:

: 88393-56-0
(2R,3R)-N¹,N⁴-dibenzyl-2,3-dihydroxysuccinamide

: 460048-60-6
formic acid 1-benzylcarbamoyl-2-isocyano-propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: H₅IO₆ / ethanol; diethyl ether / 24 h / 20 °C

2.1: 29.0 g / KF/Al₂O₃ / 48 h / 20 °C

3.1: H₂; HCOOH / 10 percent Pd/C; P-2 Ni / methanol / 12 h / 20 °C / 3040 Torr

3.2: Zn; aq. NH₄Cl / methanol / 12 h / 20 °C

4.1: 1.68 g / imidazole; DCC; HCOOH / Et₃N / 48 h / 20 °C

5.1: POCl₃; Et₃N / CH₂Cl₂ / 0.5 h

With 1H-imidazole; aluminum oxide; potassium fluoride; formic acid; hydrogen; periodic acid; triethylamine; dicyclohexyl-carbodiimide; trichlorophosphate; palladium on activated charcoal; triethylamine; In methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1055/s-2002-31948

Reference yield:

: 100-46-9
benzylamine

: 460048-60-6
formic acid 1-benzylcarbamoyl-2-isocyano-propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95.3 percent / K₂CO₃ / methanol / 7 h / Heating

2.1: H₅IO₆ / ethanol; diethyl ether / 24 h / 20 °C

3.1: 29.0 g / KF/Al₂O₃ / 48 h / 20 °C

4.1: H₂; HCOOH / 10 percent Pd/C; P-2 Ni / methanol / 12 h / 20 °C / 3040 Torr

4.2: Zn; aq. NH₄Cl / methanol / 12 h / 20 °C

5.1: 1.68 g / imidazole; DCC; HCOOH / Et₃N / 48 h / 20 °C

6.1: POCl₃; Et₃N / CH₂Cl₂ / 0.5 h

With 1H-imidazole; aluminum oxide; potassium fluoride; formic acid; hydrogen; potassium carbonate; periodic acid; triethylamine; dicyclohexyl-carbodiimide; trichlorophosphate; palladium on activated charcoal; triethylamine; In methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1055/s-2002-31948