32331-52-5

Upstream product

• 88393-56-0 (2R,3R)-N¹,N⁴-dibenzyl-2,3-dihydroxysuccinamide 
• 141108-78-3 tert-butyl (S)-(1-(benzylamino)-3-hydroxy-1-oxopropan-2-yl)carbamate 
• 1228462-08-5 2-(methyloxidoimino)-N-(phenylmethyl)acetamide 
• 67264-80-6 N-benzyl-3,3-dimethylacrylic amide 
• 313266-11-4 N¹,N⁴-dibenzyl-2,3-dihydroxysuccinamide 
• 63008-29-7 1-(Benzylaminocarbonylmethyl)pyridinium chloride 
• 100-46-9 benzylamine 
• 32331-69-4 C₁₇H₁₉N₃O₂ 

Downstream Products

• 1205585-32-5 C₁₆H₁₆N₂O₂ 
• 1600490-84-3 N-benzyl-2-hydroxy-3-(quinolin-2-yl)propanamide 
• 102025-61-6 N-benzyl-2-hydroxy-2-(1H-indol-3-yl)acetamide 
• 1450908-81-2 (R)-N-benzyl-1-(4-methoxyphenyl)-6-methyl-4-phenyl-1,4-dihydropyridazine-3-carboxamide 
• 1414874-66-0 C₂₃H₂₅FN₄O₃ 
• 1404093-59-9 C₂₄H₂₈N₄O₃ 
• 30513-42-9 4,5-dihydro-1H-imidazole-2-carboxylic acid benzylamide 
• 645395-79-5 C₂₇H₂₆N₂OS 

Relevant academic research and scientific papers

Aldehyde-mediated bioconjugation: Via in situ generated ylides

A technically simple approach for rapid, high-yielding and site-selective bioconjugation has been developed for both in vitro and cellular applications. This method involves the generation of maleimido-phosphonium ylides via 4-nitrophenol catalysis under physiological conditions followed by their Wittig reactions with aldehyde-appended biomolecules.

Thiazolidin-5-imine Formation as a Catalyst-Free Bioorthogonal Reaction for Protein and Live Cell Labeling

A previously undescribed reaction involving the formation of a thiazolidin-5-imine linkage was developed for bioconjugation. Being highly specific and operating in aqueous media, this simple condensation reaction is used to chemoselectively label peptides, proteins, and living cells under physiological conditions without the need to use toxic catalysts or reducing reagents.

Catalytic asymmetric construction of chiral hydropyridazines via conjugate addition of N-monosubstituted hydrazones to enones

The first example of a highly enantioselective and scalable formal diaza-ene reaction between N-monosubstituted hydrazones and enones catalyzed by a simple chiral primary-second diamine salt has been developed. The catalytic process provides a highly prac

Strain-promoted cycloadditions of cyclic nitrones with cyclooctynes for labeling human cancer cells

Strain-promoted cycloadditions of cyclic nitrones with cyclooctynes proceed with rate constants up to 3.38 ± 0.31 M-1 s-1 in CD3CN, or 59 times faster than the analogous reaction of azides. This highly specific modular labeling strategy can be applied for direct labeling of proteins and for live cell imaging of cancer cells. The Royal Society of Chemistry 2011.

Access to α-functionalized glycine derivatives with arylboronic acid via imino amides

An efficient approach was developed for the α-arylation of imino amides with arylboronic acids. Different substrates were examined for this arylation reaction. For the α-arylation of N-phenylimino amide, due to the electron-withdrawing properties of the phenyl group, the tautomerization between the amide and the iminol is more difficult. Thus, low reaction rate and low conversion were observed. This phenomenon supported our previously proposed mechanism for the arylation of -amino acid derivatives. Meanwhile, this method provides an alternative approach for the synthesis of α-functionalized glycine derivatives. Georg Thieme Verlag Stuttgart.

Amino amides, peptides and peptidomimetics

Synthetic methods and compounds involving amino amides, peptides and peptidomimetics. Amino amide derivatives are prepared via the one-step three-component reaction of a glyoxamide, an amine, and an organoboron derivative. Conversion of the product to another glyoxamide intermediate allows the iterative use of this chemistry for the synthesis of peptides and peptidomimetics.

Synthesis of a peptidomimetic HCMV protease inhibitor library

The human cytomegalovirus (HCMV) protease catalyzes the maturational process of the herpes virus assembly protein and plays a key role during the manufacture of viral capsid, and so is an attractive target for potential anti-herpes-virus agents with novel structures and new mechanisms. In this work, a peptidomimetic skeleton was designed and a chemical library containing 32 compounds with different substitutions on the skeleton was prepared by the oxidation of a precursor library, which was constructed from four types of building blocks: 4 carboxylic acids, 2 amines, 2 aldehydes and 2 isocyanides, based on multicomponent condensation following liquid phase strategies. The syntheses of the key building block isocyanides are presented.