α⁶-{[3-carboxy-4-(2-methoxy-2-oxoethoxy)phenyl]methyl}-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid trimethyl ester

Base Information

• Chemical Name: α⁶-{[3-carboxy-4-(2-methoxy-2-oxoethoxy)phenyl]methyl}-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid trimethyl ester
• CAS No.: 566916-83-4
• Molecular Formula: C₃₁H₄₀N₄O₁₁
• Molecular Weight: 644.679

Synonyms:

Chemical Property of α⁶-{[3-carboxy-4-(2-methoxy-2-oxoethoxy)phenyl]methyl}-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid trimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α⁶-{[3-carboxy-4-(2-methoxy-2-oxoethoxy)phenyl]methyl}-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid trimethyl ester

There total 5 articles about α⁶-{[3-carboxy-4-(2-methoxy-2-oxoethoxy)phenyl]methyl}-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid trimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

bromoacetic acid methyl ester (96-32-2) + silver carbonate + α-[(4-hydroxyphenyl)methyl]-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-6-acetic acid methyl ester → α6-{[3-carboxy-4-(2-methoxy-2-oxoethoxy)phenyl]methyl}-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid trimethyl ester (566916-83-4)

Guidance literature:

In acetonitrile; for 2h;

DOI:10.1002/hlca.200390061

Reference yield:

L-Tyr-OMe (1080-06-4) → α6-{[3-carboxy-4-(2-methoxy-2-oxoethoxy)phenyl]methyl}-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid trimethyl ester (566916-83-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / toluene / 6 h / Heating

2: 93 percent / iPr₂EtN / acetonitrile / 1 h / Heating

3: 62 percent / K₂CO₃ / acetonitrile / 6 h / Heating

4: 99 percent / aq. HBr; phenol; AcOH / 18 h / 60 °C

5: 58 percent / acetonitrile / 2 h

With hydrogen bromide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; phenol; In toluene; acetonitrile;

DOI:10.1002/hlca.200390061

Reference yield:

L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → α6-{[3-carboxy-4-(2-methoxy-2-oxoethoxy)phenyl]methyl}-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid trimethyl ester (566916-83-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 80 percent / SOCXl₂ / 2.5 h / 20 °C

2: 90 percent / toluene / 6 h / Heating

3: 93 percent / iPr₂EtN / acetonitrile / 1 h / Heating

4: 62 percent / K₂CO₃ / acetonitrile / 6 h / Heating

5: 99 percent / aq. HBr; phenol; AcOH / 18 h / 60 °C

6: 58 percent / acetonitrile / 2 h

With SOCXl₂; hydrogen bromide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; phenol; In toluene; acetonitrile;

DOI:10.1002/hlca.200390061

upstream raw materials:

bromoacetic acid methyl ester

L-Tyr-OMe

L-tyrosine

O-[(tert-butyl)dimethylsilyl]-N,N-bis{2-{[(4-methoxyphenyl)sulfonyl]amino}ethyl}-L-tyrosine methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 566916-83-4 α⁶-{[3-carboxy-4-(2-methoxy-2-oxoethoxy)phenyl]methyl}-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid trimethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send