6725-44-6

Basic information

• Product Name: Methyl 3,4-dichlorophenylacetate
• Synonyms: METHYL 3,4-DICHLOROPHENYLACETATE;3,4-DICHLOROPHENYLACETIC ACID METHYL ESTER;Dichlorophenyl acetic acid methyl ester;Methyl 3,4-dichlorophenylacetate, 97+%;Methyl2-(3,4-dichlorophenyl)acetate;Methyl 3,4-dichlorophenylacetate,99%
• CAS NO: 6725-44-6
• Molecular Formula: C₉H₈Cl₂O₂
• Molecular Weight: 219.06
• Product Categories: Aromatic Esters
• Mol File: 6725-44-6.mol
• Article Data: 25

Chemical Properties

• Melting Point: 25-27
• Boiling Point: 314.25°C (rough estimate)
• Flash Point: 112.8 °C
• Appearance: Clear colorless to light yellow/Liquid After Melting
• Density: 1.54-1.542
• Refractive Index: 1.54-1.542
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 3,4-dichlorophenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3,4-dichlorophenylacetate(6725-44-6)
• EPA Substance Registry System: Methyl 3,4-dichlorophenylacetate(6725-44-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-37-26
• Hazardous Substances Data: 6725-44-6(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

Upstream product

• 5807-30-7 3,4-dichlorophenyl acetic acid 
• 67-56-1 methanol 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 3218-49-3 3,4-dichloro-benzeneacetonitrile 

Downstream Products

• 695179-58-9 2-(3,4-dichloro-phenyl)-4-hydroxy-octanoic acid methyl ester 
• 695177-31-2 2-(3,4-dichloro-phenyl)-4-hydroxy-hexanoic acid methyl ester 
• 393164-93-7 methyl 2-diazo-2-(3,4-dichlorophenyl)acetate 
• 173457-29-9 2-(3,4-dichloro-phenyl)-pent-4-enoic acid methyl ester 
• 103753-78-2 3-arylbutanolide 
• 129564-33-6 2-(3,4-dichlorophenyl)acetic hydrazide 
• 574729-42-3 (3,4-Dichloro-phenyl)-succinic acid 4-tert-butyl ester 1-methyl ester 
• 1105683-51-9 methyl 2-(3,4-dichlorophenyl)hex-5-enoate 
• 86215-36-3 (+/-)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0.]hexane hydrochloride 
• 66504-44-7 (±)-1-(3,4 dichlorophenyl)-3-azabicyclo[3.1.0]-hexane-2,4-dione 
• 1449386-55-3 methyl 2-(3,4-dichlorophenyl)-3-(4-chlorophenyl)-4-nitrobutanoate 
• 1459756-80-9 methyl 2-(3,4-dichlorophenyl)-3-(3-chlorophenyl)-4-nitrobutanoate 
• 1459756-81-0 methyl 2-(3,4-dichlorophenyl)-3-(2-chlorophenyl)-4-nitrobutanoate 
• 625113-80-6 2-(3,4-dichloro-phenyl)-3-[3-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-propionic acid methyl ester 

Relevant articles and documents

CHIMERIC COMPOUNDS AND METHODS OF MANAGING NEUROLOGICAL DISORDERS OR CONDITIONS

This disclosure relates to chimeric compounds and methods for managing neurological conditions. In certain embodiments, the compound comprises a chemical structure of a monoamine reuptake inhibitor conjugated to a chemical structure of a histone deacetyla

Site-Selective Cross-Coupling of Remote Chlorides Enabled by Electrostatically Directed Palladium Catalysis

Control of site-selectivity in chemical reactions that occur remote from existing functionality remains a major challenge in synthetic chemistry. We describe a strategy that enables three of the most commonly used cross-coupling processes to occur with high site-selectivity on dichloroarenes that bear acidic functional groups. We have achieved this by repurposing an established sulfonylated phosphine ligand to exploit its inherent bifunctionality. Mechanistic studies suggest that the sulfonate group engages in attractive electrostatic interactions with the cation associated with the deprotonated substrate, guiding cross-coupling to the chloride at the arene meta position. This counterintuitive combination of anionic ligand and anionic substrate demonstrates an alternative design principle when considering the application of noncovalent interactions to direct catalysis.

Synergistic Catalysis for the Umpolung Trifluoromethylthiolation of Tertiary Ethers

The first transition-metal-free, site-specific umpolung trifluoromethylthiolation of tertiary alkyl ethers has been developed, achieving the challenging tertiary C(sp3)–SCF3 coupling under redox-neutral conditions. The synergism of organophotocatalyst 4CzIPN and BINOL-based phosphorothiols can site-selectively cleave tertiary sp3 C(sp3)–O ether bonds in complex molecules initiated by a polarity-matching hydrogen-atom-transfer (HAT) event. The incorporation of several competing benzylic and methine C(sp3)?H bonds in alkyl ethers has little influence on the regioselectivity. Selective difluoromethylthiolation of C?O bonds has also been achieved. This represents not only an important step forward in trifluoromethylthiolation but also a promising means for site-selective C?O bond functionalization of unsymmetrical tertiary alkyl ethers.