1H-Pyrrole-2-carboxylic acid, 3-(2-chloroethyl)-5-[[3-(2-chloroethyl)-5-[(1,1-dimethylethoxy)carbonyl]-4 -methyl-1H-pyrrol-2-yl]methyl]-4-methyl-, phenylmethyl ester

Base Information

Chemical Name:1H-Pyrrole-2-carboxylic acid, 3-(2-chloroethyl)-5-[[3-(2-chloroethyl)-5-[(1,1-dimethylethoxy)carbonyl]-4 -methyl-1H-pyrrol-2-yl]methyl]-4-methyl-, phenylmethyl ester
CAS No.:104834-59-5
Molecular Formula:C28H34Cl2N2O4
Molecular Weight:533.495
Hs Code.:
Mol file:104834-59-5.mol

1H-Pyrrole-2-carboxylic acid,
3-(2-chloroethyl)-5-[[3-(2-chloroethyl)-5-[(1,1-dimethylethoxy)carbonyl]-4
-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-, phenylmethyl ester

Synonyms:

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Chemical Property of 1H-Pyrrole-2-carboxylic acid, 3-(2-chloroethyl)-5-[[3-(2-chloroethyl)-5-[(1,1-dimethylethoxy)carbonyl]-4 -methyl-1H-pyrrol-2-yl]methyl]-4-methyl-, phenylmethyl ester

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MSDS Files:: SDS file from LookChem

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Technology Process of 1H-Pyrrole-2-carboxylic acid, 3-(2-chloroethyl)-5-[[3-(2-chloroethyl)-5-[(1,1-dimethylethoxy)carbonyl]-4 -methyl-1H-pyrrol-2-yl]methyl]-4-methyl-, phenylmethyl ester

There total 4 articles about 1H-Pyrrole-2-carboxylic acid, 3-(2-chloroethyl)-5-[[3-(2-chloroethyl)-5-[(1,1-dimethylethoxy)carbonyl]-4 -methyl-1H-pyrrol-2-yl]methyl]-4-methyl-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 92735-21-2
t-butyl 5-acetoxymethyl-4-(2'-chloroethyl)-3-methylpyrrole-2-carboxylate

: 104834-45-9
benzyl 3-(2-chloroethyl)-4-methylpyrrole-2-carboxylate

: 104834-59-5
tert-butyl 5'-<(benzyloxy)carbonyl>-3,4'-bis(2-chloroethyl)-3',4-dimethylpyrromethane-5-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; In acetic acid; at 40 ℃; for 4h;
DOI:10.1021/jo00374a031

Reference yield:

: 89909-57-9
tert-butyl 2-<(benzyloxy)carbonyl>-3-(2-chloroethyl)-4-methylpyrrole-5-carboxylate

: 104834-59-5
tert-butyl 5'-<(benzyloxy)carbonyl>-3,4'-bis(2-chloroethyl)-3',4-dimethylpyrromethane-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / trifluoroacetic acid / 1 h / 50 °C

2: 94 percent / sodium bicarbonate, iodine / methanol; H₂O / 7.5 h / 60 °C

3: 56 percent / sodium acetate trihydrate, H₂ / Adams catalyst / methanol / 15 h / 25 °C / 760 Torr

4: 84 percent / p-toluenesulfonic acid monohydrate / acetic acid; acetic acid / 4 h / 40 °C

With hydrogen; iodine; sodium acetate; sodium hydrogencarbonate; toluene-4-sulfonic acid; trifluoroacetic acid; platinum(IV) oxide; In methanol; water; acetic acid;
DOI:10.1021/jo00374a031

Reference yield:

: 104834-46-0
2-<(benzyloxy)carbonyl>-3-(2-chloroethyl)-4-methylpyrrole-5-carboxylic acid

: 104834-59-5
tert-butyl 5'-<(benzyloxy)carbonyl>-3,4'-bis(2-chloroethyl)-3',4-dimethylpyrromethane-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / sodium bicarbonate, iodine / methanol; H₂O / 7.5 h / 60 °C

2: 56 percent / sodium acetate trihydrate, H₂ / Adams catalyst / methanol / 15 h / 25 °C / 760 Torr

3: 84 percent / p-toluenesulfonic acid monohydrate / acetic acid; acetic acid / 4 h / 40 °C

With hydrogen; iodine; sodium acetate; sodium hydrogencarbonate; toluene-4-sulfonic acid; platinum(IV) oxide; In methanol; water; acetic acid;
DOI:10.1021/jo00374a031