D-Proline, 1-[N-[N-[8-(1,1-dimethylethoxy)-1,8-dioxo-2-[[(phenylmethoxy)carbonyl] amino]octyl]-2-methylalanyl]-L-phenylalanyl]-, (S)-

Base Information

Chemical Name:D-Proline, 1-[N-[N-[8-(1,1-dimethylethoxy)-1,8-dioxo-2-[[(phenylmethoxy)carbonyl] amino]octyl]-2-methylalanyl]-L-phenylalanyl]-, (S)-
CAS No.:104849-01-6
Molecular Formula:C38H52N4O9
Molecular Weight:708.852
Hs Code.:
Mol file:104849-01-6.mol

Synonyms:

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Chemical Property of D-Proline, 1-[N-[N-[8-(1,1-dimethylethoxy)-1,8-dioxo-2-[[(phenylmethoxy)carbonyl] amino]octyl]-2-methylalanyl]-L-phenylalanyl]-, (S)-

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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of D-Proline, 1-[N-[N-[8-(1,1-dimethylethoxy)-1,8-dioxo-2-[[(phenylmethoxy)carbonyl] amino]octyl]-2-methylalanyl]-L-phenylalanyl]-, (S)-

There total 2 articles about D-Proline, 1-[N-[N-[8-(1,1-dimethylethoxy)-1,8-dioxo-2-[[(phenylmethoxy)carbonyl] amino]octyl]-2-methylalanyl]-L-phenylalanyl]-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 104874-88-6
N-(benzyloxycarbonyl)-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-α-aminoisobutyryl-L-phenylalanyl-D-proline methyl ester

: 104849-01-6
N-(benzyloxycarbonyl)-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-α-aminoisobutyryl-L-phenylalanyl-D-proline

Guidance literature:: With sodium hydroxide; In methanol; Ambient temperature;
DOI:10.1021/jm00384a013

Reference yield:

: 49645-27-4
(S)-2-(((benzyloxy)carbonyl)amino)-8-(tert-butoxy)-8-oxooctanoic acid

: 104849-01-6
N-(benzyloxycarbonyl)-L-2-amino-7-(tert-butyloxycarbonyl)heptanoyl-α-aminoisobutyryl-L-phenylalanyl-D-proline

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N, N-(ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline (EEDQ) / ethyl acetate / 27 h / 0 - 20 °C

2: 96 percent / 1.0 N aq. NaOH / methanol / Ambient temperature

With sodium hydroxide; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In methanol; ethyl acetate;
DOI:10.1021/jm00384a013