(R)-2-Amino-3-(3-fluorophenyl_propionicacidethylester

Base Information

• Chemical Name: (R)-2-Amino-3-(3-fluorophenyl_propionicacidethylester
• CAS No.: 104880-96-8
• Molecular Formula: C11H14FNO2
• Molecular Weight: 211.23300
• Mol file: 104880-96-8.mol

Synonyms:

Chemical Property of (R)-2-Amino-3-(3-fluorophenyl_propionicacidethylester

Chemical Property:

• PSA: 52.32000
• LogP: 1.95890

Purity/Quality:

98%min ^*data from raw suppliers

ETHYL-(2R)-2-AMINO-3-(3-FLUOROPHENYL)PROPANOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-Amino-3-(3-fluorophenyl_propionicacidethylester

There total 6 articles about (R)-2-Amino-3-(3-fluorophenyl_propionicacidethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ethyl 3-(3-fluorophenyl)-2-(hydroxyimino)propanoate → (±)-ethyl 2-amino-3-(3-fluorophenyl)propanoate (104880-96-8)

Guidance literature:

With hydrogenchloride; zinc; In ethanol; water; at 0 ℃; for 3h;

DOI:10.3762/bjoc.14.264

Reference yield: 89.0%

→ (±)-ethyl 2-amino-3-(3-fluorophenyl)propanoate (104880-96-8)

Guidance literature:

With hydrogenchloride; zinc; In ethanol; for 2h;

Reference yield: 79.0%

ethanol (64-17-5) + 3-fluorophenylalanine (456-88-2,2629-54-1) → (±)-ethyl 2-amino-3-(3-fluorophenyl)propanoate (104880-96-8)

Guidance literature:

With thionyl chloride; at -5 ℃; for 3h; Reflux;

DOI:10.1021/jo502912m

upstream raw materials:

ethanol

3-fluorophenylalanine

diethyl 2-(3-fluorobenzyl)malonate

Refernces

• 1、 -. "IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS". Page/Page column 60; 63. . Retrieved 2018/11/22.
• 2、 Li, Kaizhi,Tan, Guangying,Huang, Jingsheng,Song, Feijie,You, Jingsong. "Iron-catalyzed oxidative C - H/C - H cross-coupling: An efficient route to α-quaternary α-amino acid derivatives". supporting information. p. 12942 - 12945. Retrieved 2014/01/06.