3-Benzyl-8-(1S,2S,4S)-bicyclo[2.2.1]hept-5-en-2-yl-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

Base Information

• Chemical Name: 3-Benzyl-8-(1S,2S,4S)-bicyclo[2.2.1]hept-5-en-2-yl-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione
• CAS No.: 595566-44-2
• Molecular Formula: C₂₈H₃₈N₄O₃Si
• Molecular Weight: 506.72
• Mol file: 595566-44-2.mol

Synonyms:

Chemical Property of 3-Benzyl-8-(1S,2S,4S)-bicyclo[2.2.1]hept-5-en-2-yl-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Benzyl-8-(1S,2S,4S)-bicyclo[2.2.1]hept-5-en-2-yl-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

There total 1 articles about 3-Benzyl-8-(1S,2S,4S)-bicyclo[2.2.1]hept-5-en-2-yl-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) + 3-Benzyl-8-(1S,2S,4S)-bicyclo[2.2.1]hept-5-en-2-yl-1-propyl-3,7-dihydro-purine-2,6-dione → 3-Benzyl-8-(1S,2S,4S)-bicyclo[2.2.1]hept-5-en-2-yl-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione (595566-44-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00639-X

Reference yield:

3-Benzyl-8-(1S,2S,4S)-bicyclo[2.2.1]hept-5-en-2-yl-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione (595566-44-2) → 4-[5-((1R,2S,4S)-8-Bicyclo[2.2.1]hept-2-yl-2,6-dioxo-1-propyl-1,2,6,7-tetrahydro-purin-3-yl)-pentanoyl]-benzenesulfonyl fluoride

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium formate; 10 percent Pd/C / methanol / Heating

2: K₂CO₃ / dimethylformamide

3: aq. HCl

With hydrogenchloride; palladium on activated charcoal; ammonium formate; potassium carbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00639-X

Reference yield:

3-Benzyl-8-(1S,2S,4S)-bicyclo[2.2.1]hept-5-en-2-yl-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione (595566-44-2) → 4-{5-[(1R,2S,4S)-8-Bicyclo[2.2.1]hept-2-yl-2,6-dioxo-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,2,6,7-tetrahydro-purin-3-yl]-pentanoyl}-benzenesulfonyl fluoride (595570-77-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium formate; 10 percent Pd/C / methanol / Heating

2: K₂CO₃ / dimethylformamide

With palladium on activated charcoal; ammonium formate; potassium carbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00639-X

upstream raw materials:

(2-trimethylethylsilylethoxy)methyl chloride

Downstream raw materials:

4-{5-[(1R,2S,4S)-8-Bicyclo[2.2.1]hept-2-yl-2,6-dioxo-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,2,6,7-tetrahydro-purin-3-yl]-pentanoyl}-benzenesulfonyl fluoride