C₂₁H₁₇Cl₂NO₃

Base Information

• Chemical Name: C₂₁H₁₇Cl₂NO₃
• CAS No.: 1173794-94-9
• Molecular Formula: C₂₁H₁₇Cl₂NO₃
• Molecular Weight: 402.277
• Mol file: 1173794-94-9.mol

Synonyms:

Chemical Property of C₂₁H₁₇Cl₂NO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₁₇Cl₂NO₃

There total 10 articles about C₂₁H₁₇Cl₂NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

C22H19Cl2NO3 (1173794-92-7) → C21H17Cl2NO3 (1173794-94-9)

Guidance literature:

With sodium hydroxide; In ethanol;

DOI:10.1016/j.bmcl.2009.04.050

Reference yield:

C14H9Cl2NO2 (1173794-86-9) → C21H17Cl2NO3 (1173794-94-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: water; sodium hydroxide / 2 h / Reflux

2.1: toluene-4-sulfonic acid / 3 h / 80 °C

3.1: triphenylphosphine; diethylazodicarboxylate / diethyl ether / 20 °C

4.1: sodium hydroxide / tetrahydrofuran / 20 °C

4.2: 20 °C

With water; toluene-4-sulfonic acid; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; 3.1: Mitsunobu reaction;

DOI:10.1016/j.cclet.2010.11.008

Reference yield:

C15H12Cl3NO2 (1173794-83-6) → C21H17Cl2NO3 (1173794-94-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / 2.5 h / 160 - 250 °C / Inert atmosphere

2.1: water; sodium hydroxide / 2 h / Reflux

3.1: toluene-4-sulfonic acid / 3 h / 80 °C

4.1: triphenylphosphine; diethylazodicarboxylate / diethyl ether / 20 °C

5.1: sodium hydroxide / tetrahydrofuran / 20 °C

5.2: 20 °C

With aluminum (III) chloride; water; toluene-4-sulfonic acid; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; 4.1: Mitsunobu reaction;

DOI:10.1016/j.cclet.2010.11.008

upstream raw materials:

C₂₂H₁₉Cl₂NO₃

C₁₅H₁₂Cl₃NO₂

C₁₄H₉Cl₂NO₂

4-hydroxydiclofenac