1-isopropyl-2-(1-phenyl-3,4,4-trifluoro-4-cyclobutene)-o-carborane

Base Information

• Chemical Name: 1-isopropyl-2-(1-phenyl-3,4,4-trifluoro-4-cyclobutene)-o-carborane
• CAS No.: 111278-54-7
• Molecular Formula: C₁₅H₂₃B₁₀F₃
• Molecular Weight: 368.453
• Mol file: 111278-54-7.mol

Synonyms:

Chemical Property of 1-isopropyl-2-(1-phenyl-3,4,4-trifluoro-4-cyclobutene)-o-carborane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-isopropyl-2-(1-phenyl-3,4,4-trifluoro-4-cyclobutene)-o-carborane

There total 1 articles about 1-isopropyl-2-(1-phenyl-3,4,4-trifluoro-4-cyclobutene)-o-carborane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-isopropyl-ortho-carboranyllithium (56792-36-0) + 1-phenyl-3,3,4-trifluoro-4-chloro-1-cyclobutene (313-27-9) → 1-isopropyl-2-(1-phenyl-3,4,4-trifluoro-4-cyclobutene)-o-carborane (111278-54-7)

Guidance literature:

In diethyl ether; benzene; soln. of (CH(CH3)2)CC(Li)B10H10 in benzene added to soln. of C4HF3Cl(C6H5) in ether at -20°C, stirred for 2 h at 20°C; mixture decomposed with H2O, ether-benzene layer separated, dried over CaCl2, solvents evapd., elem. anal.;

DOI:10.1007/BF01474232

Reference yield: 71.0%

1-isopropyl-2-(1-phenyl-3,4,4-trifluoro-4-cyclobutene)-o-carborane (111278-54-7) → 1-isopropyl-2-(1-phenyl-2-fluorocyclobut-1-en-3-one)-o-carborane (111278-56-9)

Guidance literature:

With sulfuric acid; In sulfuric acid; conc. H2SO4 added to (CH(CH3)2)CC(C4HF3(C6H5))B10H10, stirred for 1 h at 100°C and for 1 h at 110°C; mixture poured onto ice, extracted with ether, extract dried over MgSO4, ether removed, elem. anal.;

DOI:10.1007/BF01474232

Reference yield: 45.0%

1-isopropyl-2-(1-phenyl-3,4,4-trifluoro-4-cyclobutene)-o-carborane (111278-54-7) + mercury(II) diacetate (1600-27-7) → 1-isopropyl-2-(1-phenyl-2-fluorocyclobut-1-en-3-one)-o-carborane (111278-56-9)

Guidance literature:

With sodium hydrogencarbonate; In further solvent(s); mixture of CF3COOH and (CH3COO)2Hg added to (CH(CH3)2)CC(C4HF3(C6H5))B10H10, mixture heated for 2 hat 50°C; solvent removed in vacuum, ether and aq. NaHCO3 added, ethereal layer separated, dried over MgSO4;

DOI:10.1007/BF01474232

upstream raw materials:

1-isopropyl-ortho-carboranyllithium

1-phenyl-3,3,4-trifluoro-4-chloro-1-cyclobutene

Downstream raw materials:

1-isopropyl-2-(1-phenyl-2-fluorocyclobut-1-en-3-one)-o-carborane