Technology Process of 1-(4-methoxy-3-triisopropylsilyloxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
There total 3 articles about 1-(4-methoxy-3-triisopropylsilyloxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile;
With
potassium hexamethylsilazane;
In
tetrahydrofuran;
at -78 ℃;
for 0.0833333h;
Inert atmosphere;
4-methoxy-3-(triisopropylsilanyloxy)benzyl bromide;
In
tetrahydrofuran;
at -78 ℃;
Inert atmosphere;
DOI:10.1002/ejoc.201101183
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 0.33 h / 0 - 20 °C / Inert atmosphere
2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere
2.2: -78 °C / Inert atmosphere
With
N-Bromosuccinimide; potassium hexamethylsilazane; triphenylphosphine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.201101183
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium tetrahydroborate / ethanol / 2 h / 20 °C / Inert atmosphere
2.1: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 0.33 h / 0 - 20 °C / Inert atmosphere
3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere
3.2: -78 °C / Inert atmosphere
With
sodium tetrahydroborate; N-Bromosuccinimide; potassium hexamethylsilazane; triphenylphosphine;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1002/ejoc.201101183
