(1S)-1-[4-(5-{[(1S)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-2-methoxyphenoxy)benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: (1S)-1-[4-(5-{[(1S)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-2-methoxyphenoxy)benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 59654-05-6
• Molecular Formula: C₃₉H₄₆N₂O₆
• Molecular Weight: 638.804

Synonyms:(+)-O-Methylthalibrine;O-Methylthalibrine

Chemical Property of (1S)-1-[4-(5-{[(1S)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-2-methoxyphenoxy)benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

• Vapor Pressure: 1.91E-20mmHg at 25°C
• Boiling Point: 717.6°C at 760 mmHg
• Flash Point: 173.2°C
• Density: 1.156g/cm³

Purity/Quality:

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Technology Process of (1S)-1-[4-(5-{[(1S)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-2-methoxyphenoxy)benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

There total 22 articles about (1S)-1-[4-(5-{[(1S)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-2-methoxyphenoxy)benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

(S)-(+)-1-(4-bromobenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (1344118-40-6) + (S)-(+)-1-(3-hydroxy-4-methoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (3122-95-0) → (+)-O-methylthalibrine (59654-05-6)

Guidance literature:

With copper(l) iodide; dimethylaminoacetic acid; caesium carbonate; In ethyl methyl ether; at 160 ℃; for 1.5h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/jo201871c

Reference yield:

→ (DL)(LD)-dl-O,O,O-Trimethylberbamunin (2202-17-7,7777-01-7,13565-64-5,21124-22-1,49648-16-0,59654-05-6)

Guidance literature:

dl-4'-O-Methylberbamunin, Diazomethan;

Reference yield:

→ O-Methyl-dauricin (2202-17-7,7777-01-7,13565-64-5,21124-22-1,49648-16-0,59654-05-6)

Guidance literature:

Dauricin/THF, CH2N2;

DOI:10.1248/yakushi1947.84.10_1030

upstream raw materials:

4-methoxy-3-(triisopropylsilanyloxy)benzyl bromide

1-(4-methoxy-3-triisopropylsilyloxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

(S)-(-)-1-[4-methoxy-3-(triisopropylsilanyloxy)benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

(S)-(-)-1-(4-bromobenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

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