Technology Process of 3-(2-amino-6-o-tolylquinolin-3-yl)-N-(cyclohexylmethyl)propanamide
There total 14 articles about 3-(2-amino-6-o-tolylquinolin-3-yl)-N-(cyclohexylmethyl)propanamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.17 h / Inert atmosphere; Reflux
2: p-toluenesulfonylanhydride / α,α,α-trifluorotoluene / 0.33 h / Inert atmosphere
3: trifluoroacetic acid / 0.33 h / Reflux; Inert atmosphere
With
p-toluenesulfonylanhydride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
chloroform; α,α,α-trifluorotoluene;
DOI:10.1021/jm200544q
- Guidance literature:
-
Multi-step reaction with 6 steps
1: thionyl chloride / 0.5 h / Reflux; Inert atmosphere
2: dichloromethane / 0.25 h / Inert atmosphere
3: palladium 10% on activated carbon; hydrogen / methanol / 0.5 h / Inert atmosphere
4: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.17 h / Inert atmosphere; Reflux
5: p-toluenesulfonylanhydride / α,α,α-trifluorotoluene / 0.33 h / Inert atmosphere
6: trifluoroacetic acid / 0.33 h / Reflux; Inert atmosphere
With
thionyl chloride; palladium 10% on activated carbon; p-toluenesulfonylanhydride; hydrogen; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
methanol; dichloromethane; chloroform; α,α,α-trifluorotoluene;
DOI:10.1021/jm200544q
- Guidance literature:
-
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 0.5 h / Inert atmosphere
2: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.17 h / Inert atmosphere; Reflux
3: p-toluenesulfonylanhydride / α,α,α-trifluorotoluene / 0.33 h / Inert atmosphere
4: trifluoroacetic acid / 0.33 h / Reflux; Inert atmosphere
With
palladium 10% on activated carbon; p-toluenesulfonylanhydride; hydrogen; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
methanol; chloroform; α,α,α-trifluorotoluene;
DOI:10.1021/jm200544q
