3-[2-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4-imidazolidinedione acetic acid salt

Base Information

Chemical Name:3-[2-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4-imidazolidinedione acetic acid salt
CAS No.:457658-56-9
Molecular Formula:C₂H₄O₂*C₂₈H₃₉N₃O₆
Molecular Weight:573.687
Hs Code.:

3-[2-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4-imidazolidinedione acetic acid salt

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Chemical Property of 3-[2-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4-imidazolidinedione acetic acid salt

Chemical Property:

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Technology Process of 3-[2-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4-imidazolidinedione acetic acid salt

There total 9 articles about 3-[2-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4-imidazolidinedione acetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 457645-07-7
C₁₁H₁₃IN₂O₃

: 457658-56-9
3-[2-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4-imidazolidinedione acetic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / ethanol; water

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

3: N,N-dimethyl-formamide

4: platinum(IV) oxide; hydrogen / ethyl acetate / Enzymatic reaction

5: water / 75 °C

With platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide; 2: Sonogashira coupling;
DOI:10.1016/j.bmc.2011.05.064

Reference yield:

: 457645-08-8
3-(2-iodophenyl)-2,4-imidazolidinedione

: 457658-56-9
3-[2-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4-imidazolidinedione acetic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: N,N-dimethyl-formamide

3: platinum(IV) oxide; hydrogen / ethyl acetate / Enzymatic reaction

4: water / 75 °C

With platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; N-ethyl-N,N-diisopropylamine; In water; ethyl acetate; N,N-dimethyl-formamide; 1: Sonogashira coupling;
DOI:10.1016/j.bmc.2011.05.064

Reference yield:

: 208925-08-0
(2R)-hydroxy-2-(2,2-dimethyl-4H-1,3-benzodioxine-6-yl)-ethylamine

: 457658-56-9
3-[2-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4-imidazolidinedione acetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide

2: platinum(IV) oxide; hydrogen / ethyl acetate / Enzymatic reaction

3: water / 75 °C

With platinum(IV) oxide; hydrogen; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.064