[(2S,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl]-phosphonic acid monomethyl ester

Base Information

• Chemical Name: [(2S,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl]-phosphonic acid monomethyl ester
• CAS No.: 854389-59-6
• Molecular Formula: C₃₃H₃₇N₂O₁₀P
• Molecular Weight: 652.638
• Mol file: 854389-59-6.mol

Synonyms:

Chemical Property of [(2S,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl]-phosphonic acid monomethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(2S,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl]-phosphonic acid monomethyl ester

There total 1 articles about [(2S,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl]-phosphonic acid monomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

1-{(2R,3R,5S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione (854389-58-5) + dimethyl <<(p-tolylsulfonyl)oxy>methyl>phosphonate (80792-13-8) → [(2S,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(3,5-dimethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl]-phosphonic acid monomethyl ester + [(2S,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl]-phosphonic acid monomethyl ester (854389-59-6)

Guidance literature:

1-{(2R,3R,5S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione; dimethyl <<(p-tolylsulfonyl)oxy>methyl>phosphonate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

With pyridine; In water; at 50 ℃; for 16h;

DOI:10.1081/NCN-200033912

Reference yield:

[(2S,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl]-phosphonic acid monomethyl ester (854389-59-6) → 4-methoxy-1-oxy-2-pyridylmethyl 3-deoxy-2-O-(4,4'-dimethoxytrityl)-1-(thymin-1-yl)-β-D-erythro-pentofuranos-5-yloxymethylphosphonate

Guidance literature:

Multi-step reaction with 2 steps

1: 4-methoxy-pyridine 1-oxide; 2-chloro-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide; pyridine / 20 °C

2: 0.526 g / pyridine / H₂O / 16 h / 50 - 60 °C

With pyridine; 4-methoxypyridine N-oxide; 2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide; In water;

DOI:10.1081/NCN-200033912

Reference yield:

[(2S,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl]-phosphonic acid monomethyl ester (854389-59-6) + 4-methoxy-1-oxido-2-pyridylmethanol (64364-95-0) → [(2S,4R,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl]-phosphonic acid 4-methoxy-1-oxy-pyridin-2-ylmethyl ester methyl ester

Guidance literature:

With pyridine; 4-methoxypyridine N-oxide; 2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide; at 20 ℃;

DOI:10.1081/NCN-200033912

upstream raw materials:

1-{(2R,3R,5S)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-hydroxymethyl-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

dimethyl <<(p-tolylsulfonyl)oxy>methyl>phosphonate