64364-95-0

Usage

Uses

Used in Chemical Research:
2-Pyridinemethanol, 4-methoxy-, 1-oxide (9CI) is used as a research compound for studying its physical and chemical properties, such as melting point, boiling point, density, and molecular weight. These properties can vary based on different conditions, making it an interesting subject for scientific investigation.
Used in Pharmaceutical Industry:
2-Pyridinemethanol, 4-methoxy-, 1-oxide (9CI) is used as an intermediate or building block in the synthesis of various pharmaceutical compounds. Its unique structure and properties can contribute to the development of new drugs with potential therapeutic applications.
Used in Material Science:
2-Pyridinemethanol, 4-methoxy-, 1-oxide (9CI) is used as a component in the development of new materials with specific properties, such as improved stability, reactivity, or selectivity. Its incorporation into materials can lead to advancements in various industries, including electronics, energy, and environmental protection.
Used in Analytical Chemistry:
2-Pyridinemethanol, 4-methoxy-, 1-oxide (9CI) is used as a reference compound or standard in analytical chemistry for the calibration of instruments and the development of new analytical methods. Its well-defined structure and properties make it a valuable tool for accurate measurements and reliable results.

Upstream product

• 77345-69-8 2-formyl-4-methoxypyridine-1-oxide 
• 5470-66-6 2-methyl-4-nitropyridine N-oxide 
• 931-19-1 2-methylpyridine N-oxide 
• 76133-00-1 2-formyl-4-nitropyridine ethylene acetal 1-oxide 
• 77345-73-4 4-methoxy-2-formylpyridine ethylene acetal 1-oxide 
• 65227-58-9 2-formyl-4-nitropyridine 1-oxide 
• 124-41-4 sodium methylate 
• 77345-71-2 4-nitro-2-pyridylmethanol 1-oxide 

Downstream Products

• 184159-50-0 ({{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid 4-methoxy-1-oxy-pyridin-2-ylmethyl ester phenyl ester 
• 184159-51-1 [([2-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-amino)-methyl]-phosphonic acid 4-methoxy-1-oxy-pyridin-2-ylmethyl ester phenyl ester 

Relevant academic research and scientific papers

Large-scale synthesis of a key catalytic reagent for phosphorus protection in building blocks for isopolar phosphonate oligonucleotide preparation

A simple procedure for the large-scale synthesis of 4-methoxy-2-pyridinemethanol 1-oxide (5), a key compound in modern triester synthesis of oligonucleotides, employing Buechi R 152 evaporator as a reaction apparatus was elaborated. Two crucial reaction steps, both strongly exothermic, were satisfactorily handled. Our procedure provides a high-purity, light-and heat-stable product in a satisfactory yield.

Protecting Groups in Nucleosides and Nucleotides Synthesis. VIII. Synthesis of (4-Substituted 2-Picolyl 1-Oxide)halides and 2'- and 3'-O-(4-Substituted-2-picolyl 1-Oxide)nucleosides

A number of alkylating agents of the 4-substituted pyridine N-oxide series, such as (4-nitro-, 4-methylthio-, or 4-methoxy-2-picolyl 1-oxide)halide, have been prepared.Treatment of 2',3'-O-(dibutylstannylene)uridine or 2',3'-O-(dibutylstannylene)adenosine with the alkylating agents afforded the corresponding 2'-O- and 3'-O-(4-substituted 2-picolyl 1-oxide)nucleosides. 2'-O-(4-Nitro-2-picolyl 1-oxide)uridine was converted to the 4-methoxy-2-picolyl derivative on treatment with methanolic sodium methoxide at 60 deg C.However, it was found that the treatment of adenosine with sodium hydride in DMF, followed by alkylation with (4-methoxy-2-picolyl 1-oxide)chloride gave a more satisfactory yield (56.4percent) of 2'-O-(4-methoxy-2-picolyl 1-oxide)adenosine. 2'-O-(4-Methylthio-2-picolyl 1-oxide)adenosine could be similarly prepared in 36.7percent yield. 4-Methoxy-2-picolyl protection was removable under milder conditions than 2-picolyl 1-oxide protection.Phosphorylation of 17 with phosphoryl chloride in triethyl phosphate gave the corresponding 5'-phosphate in 57.8percent yield.Keywords - 4-substituted 2-picolyl 1-oxide; protecting group in nucleotide synthesis; acetic anhydride rearrangement of α-picolyl 1-oxide; 2'-O-substituted adenosine; 2'-O-substituted uridine; 4-methoxy-2-pyridyl carbinol 1-oxide; 4-methylthio-2-pyridyl carbinol 1-oxide; 4-nitro-2-pyridyl carbinol 1-oxide.