1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indol-4-yl]-3-[5-chloro-2-(trideuteriomethoxy)phenyl]urea

Base Information

Chemical Name:1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indol-4-yl]-3-[5-chloro-2-(trideuteriomethoxy)phenyl]urea
CAS No.:1362852-60-5
Molecular Formula:C₂₂H₂₀ClN₅O₂
Molecular Weight:426.846
Hs Code.:

Synonyms:

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Chemical Property of 1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indol-4-yl]-3-[5-chloro-2-(trideuteriomethoxy)phenyl]urea

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Technology Process of 1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indol-4-yl]-3-[5-chloro-2-(trideuteriomethoxy)phenyl]urea

There total 6 articles about 1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indol-4-yl]-3-[5-chloro-2-(trideuteriomethoxy)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1362855-33-1
C₁₁H₁₄⁽²⁾H₂N₂O₃

: 1362852-60-5
1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indol-4-yl]-3-[5-chloro-2-(trideuteriomethoxy)phenyl]urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0 - 20 °C

2.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 0.17 h / 20 °C

4.1: trifluoroacetic acid / 1 h / 20 °C

4.2: 0.5 h / pH 7 - 8

With carbon tetrabromide; sodium hydrogencarbonate; triphenylphosphine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 5327-32-2
2-acetylamino-4-methylpyridine

: 1362852-60-5
1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indol-4-yl]-3-[5-chloro-2-(trideuteriomethoxy)phenyl]urea

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium permanganate / water / 60 °C

2.1: boron trifluoride diethyl etherate / ethanol / Reflux

3.1: tert-butyl alcohol / 16 h / 60 °C

4.1: calcium chloride; sodium borodeuteride / d⁽⁴⁾-methanol / 0 - 20 °C

5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0 - 20 °C

6.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 3 h / 20 °C

7.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 0.17 h / 20 °C

8.1: trifluoroacetic acid / 1 h / 20 °C

8.2: 0.5 h / pH 7 - 8

With potassium permanganate; sodium borodeuteride; carbon tetrabromide; boron trifluoride diethyl etherate; sodium hydrogencarbonate; triphenylphosphine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; calcium chloride; In tetrahydrofuran; ethanol; dichloromethane; d⁽⁴⁾-methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 695-34-1
2-Amino-4-methylpyridine

: 1362852-60-5
1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indol-4-yl]-3-[5-chloro-2-(trideuteriomethoxy)phenyl]urea

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic acid / Reflux

1.2: pH 9

2.1: potassium permanganate / water / 60 °C

3.1: boron trifluoride diethyl etherate / ethanol / Reflux

4.1: tert-butyl alcohol / 16 h / 60 °C

5.1: calcium chloride; sodium borodeuteride / d⁽⁴⁾-methanol / 0 - 20 °C

6.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0 - 20 °C

7.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 3 h / 20 °C

8.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 0.17 h / 20 °C

9.1: trifluoroacetic acid / 1 h / 20 °C

9.2: 0.5 h / pH 7 - 8

With potassium permanganate; sodium borodeuteride; carbon tetrabromide; boron trifluoride diethyl etherate; sodium hydrogencarbonate; acetic acid; triphenylphosphine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; calcium chloride; In tetrahydrofuran; ethanol; dichloromethane; d⁽⁴⁾-methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;