Technology Process of (3aS,6R,6aR)-2-Benzyloxy-6-butyl-4-(1-ethoxy-ethoxy)-hexahydro-furo[3,4-b]furan
There total 13 articles about (3aS,6R,6aR)-2-Benzyloxy-6-butyl-4-(1-ethoxy-ethoxy)-hexahydro-furo[3,4-b]furan which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 13 steps
1: imidazole / dimethylformamide
2: 77 percent / m-chlorperbenzoic acid (m-CPBA), AcONa / CHCl3
3: PPTS
4: 96 percent / H2 / 10percent Pd-C / ethyl acetate
5: 81 percent / L-selectride / tetrahydrofuran / -78 °C
6: 98 percent / PPTS
7: 92 percent / n-Bu4NF / tetrahydrofuran
8: 1.)(COCl)2, DMSO, 2.)Et3N / 1.)CH2Cl2, -50 deg C
9: 88 percent / NaClO2, 2-methyl-2-butene, KH2PO4 / H2O; 2-methyl-propan-2-ol
10: 93 percent / 2percent HCl / tetrahydrofuran
11: 79 percent / p-TsOH / CH2Cl2
12: 87 percent / DIBAL / tetrahydrofuran / -78 °C
13: 83 percent / PPTS
With
1H-imidazole; hydrogenchloride; sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; sodium acetate; pyridinium p-toluenesulfonate; L-Selectride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; chloroform; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0040-4039(00)97761-X
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 77 percent / m-chlorperbenzoic acid (m-CPBA), AcONa / CHCl3
2: PPTS
3: 96 percent / H2 / 10percent Pd-C / ethyl acetate
4: 81 percent / L-selectride / tetrahydrofuran / -78 °C
5: 98 percent / PPTS
6: 92 percent / n-Bu4NF / tetrahydrofuran
7: 1.)(COCl)2, DMSO, 2.)Et3N / 1.)CH2Cl2, -50 deg C
8: 88 percent / NaClO2, 2-methyl-2-butene, KH2PO4 / H2O; 2-methyl-propan-2-ol
9: 93 percent / 2percent HCl / tetrahydrofuran
10: 79 percent / p-TsOH / CH2Cl2
11: 87 percent / DIBAL / tetrahydrofuran / -78 °C
12: 83 percent / PPTS
With
hydrogenchloride; sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; sodium acetate; pyridinium p-toluenesulfonate; L-Selectride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; chloroform; water; ethyl acetate; tert-butyl alcohol;
DOI:10.1016/S0040-4039(00)97761-X
