Technology Process of C30H26F3N5O4
There total 7 articles about C30H26F3N5O4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-Cyanobenzoic acid;
With
1,1'-carbonyldiimidazole;
In
N,N-dimethyl-formamide;
N-(4-piperidin-4-yl-3-trifluoromethylbenzoyl)-N'-(carbobenzyloxy)guanidine hydrochloride;
With
N-ethyl-N,N-diisopropylamine;
at 20 ℃;
DOI:10.1021/jm300601d
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1 h / 20 - 50 °C
1.2: 20 °C
2.1: hydrogenchloride / 1,4-dioxane / 16 h
3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide
3.2: 20 °C
With
hydrogenchloride; 2-chloro-1-methyl-pyridinium iodide; 1,1'-carbonyldiimidazole;
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;
DOI:10.1021/jm300601d
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 4 h / 140 °C
2.1: hydrogen; acetic acid; platinum(IV) oxide / 60 h / Inert atmosphere
3.1: potassium carbonate; hydrogenchloride / methanol; water / 16 h / 20 °C
4.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1 h / 20 - 50 °C
4.2: 20 °C
5.1: hydrogenchloride / 1,4-dioxane / 16 h
6.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide
6.2: 20 °C
With
hydrogenchloride; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium(0); 2-chloro-1-methyl-pyridinium iodide; hydrogen; potassium carbonate; acetic acid; 1,1'-carbonyldiimidazole;
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; water; N,N-dimethyl-formamide;
1.1: |Suzuki Coupling;
DOI:10.1021/jm300601d
