(+/-)-norsecurinine

Base Information

Chemical Name:(+/-)-norsecurinine
CAS No.:25472-13-3
Molecular Formula:C₁₂H₁₃NO₂
Molecular Weight:203.241
Hs Code.:

Synonyms:

Suppliers and Price of (+/-)-norsecurinine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-norsecurinine

Chemical Property:

Purity/Quality:

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Technology Process of (+/-)-norsecurinine

There total 21 articles about (+/-)-norsecurinine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 131989-89-4,132075-02-6,138230-51-0,138230-52-1
(±)-niruroidine

: 2650-35-3,25472-13-3,102044-56-4
(+/-)-norsecurinine

Guidance literature:: With dmap; methanesulfonyl chloride; triethylamine; In dichloromethane; for 0.25h;
DOI:10.1016/S0040-4020(01)88027-3

Reference yield: 40.0%

: C₁₈H₁₉NO₂Se

: 2650-35-3,25472-13-3,102044-56-4
(+/-)-norsecurinine

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In methanol; at -78 ℃;

Reference yield:

: 109-00-2
3-HYDROXYPYRIDINE

: 2650-35-3,25472-13-3,102044-56-4
(+/-)-norsecurinine

Guidance literature:: Multi-step reaction with 14 steps

1: 78 percent / dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 0.17 h

2: 81 percent / CH₂Cl₂ / 3 h / 25 °C

3: 45 percent / KF*2H₂O / methanol; acetic acid / 17 h

4: 1.) 2-methyl-2-butene, BH₃*THF; 2.) 30percent aq. H₂O₂, 2M NaOH / 1.) a.) 0 deg C, 1 h; b.) -23 deg C, 2.5 h; 2.) 0.5 h

5: 78 percent / Et₃N, 4-dimethylaminopyridine (DMAP) / CH₂Cl₂ / 5 h

6: 30percent HBr/AcOH, cyclohexene / 17 h

7: 90 percent / 4-methylmorpholine-N-oxide (MMNO) / OsO₄ / acetone; H₂O; 2-methyl-propan-2-ol / 4 h

8: 4-dimethylaminopyridine (DMAP), Et₃N / CH₂Cl₂ / 0.17 h

9: DMSO/(COCl)2/Et₃N, 4 Angstroem molecular sieves / CH₂Cl₂ / 1.67 h / -78 °C

10: NaBH₄ / methanol / 0.25 h / 0 °C

11: 100 percent / 4-dimethylaminopyridine (DMAP), 4 Angstroem molecular sieves / CH₂Cl₂ / 0.5 h

12: 100 percent / n-Bu₃SnH, AIBN / benzene / 0.25 h / Heating

13: 94 percent / NaOMe / methanol / 5 h / Ambient temperature

14: 91 percent / Et₃N, 4-dimethylaminopyridine (DMAP), MeSO₂Cl / CH₂Cl₂ / 0.25 h

With dmap; potassium fluoride; sodium hydroxide; sodium tetrahydroborate; borane-THF; 2-methyl-but-2-ene; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); 4 A molecular sieve; hydrogen bromide; dihydrogen peroxide; tri-n-butyl-tin hydride; sodium methylate; acetic acid; dimethyl sulfoxide; methanesulfonyl chloride; 4-methylmorpholine N-oxide; triethylamine; dicyclohexyl-carbodiimide; cyclohexene; osmium(VIII) oxide; In methanol; dichloromethane; water; acetic acid; acetone; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4020(01)88027-3