(1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2'R,3S)-1'-acetyl-2-methylspiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate

Base Information

• Chemical Name: (1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2'R,3S)-1'-acetyl-2-methylspiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate
• CAS No.: 140843-10-3
• Molecular Formula: C₃₁H₃₈N₂O₃
• Molecular Weight: 486.654
• Mol file: 140843-10-3.mol

Synonyms:

Chemical Property of (1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2'R,3S)-1'-acetyl-2-methylspiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2'R,3S)-1'-acetyl-2-methylspiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate

There total 6 articles about (1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2'R,3S)-1'-acetyl-2-methylspiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (E)-<<2-(2-methyl-1H-indol-3-yl)ethyl>imino>acetate (140924-07-8) + acetyl chloride (75-36-5) → (1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 1'-acetyl-2-methylspiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate (140843-10-3) + (1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2'R,3S)-1'-acetyl-2-methylspiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate (140843-10-3)

Guidance literature:

With 2,4,6-trimethyl-pyridine; In dichloromethane; at -78 ℃; for 48h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1002/hlca.19920750124

Reference yield:

(1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (E)-<<2-(2-methyl-1H-indol-3-yl)ethyl>imino>acetate (140924-07-8) + acetyl chloride (75-36-5) → (1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 1'-acetyl-2-methylspiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate (140843-10-3) + (1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (2'R,3S)-1'-acetyl-2-methylspiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate (140843-10-3)

Guidance literature:

With 2,4,6-trimethyl-pyridine; In dichloromethane; at -78 ℃; for 48h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1002/hlca.19920750124

Reference yield:

2-methyltryptamine (2731-06-8) → (1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 1'-acetyl-2-methylspiro<3H-indole-3,3'-pyrrolidine>-2'-carboxylate (140843-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1: molecular sieves 0.4 nm / CH₂Cl₂ / 24 h / 25 °C

2: 2,4,6-trimethylpyridine / CH₂Cl₂ / 48 h / -78 °C

With 2,4,6-trimethyl-pyridine; 4 A molecular sieve; In dichloromethane;

DOI:10.1002/hlca.19920750124

upstream raw materials:

(1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (E)-<<2-(2-methyl-1H-indol-3-yl)ethyl>imino>acetate

acetyl chloride

2-methyltryptamine

(1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl glyoxylate