L-Prolinamide, N-[[[4-(ethoxycarbonyl)phenyl]amino]carbonyl]-L-valyl-N-[3,3,3-trifluoro-2 -hydroxy-1-(1-methylethyl)propyl]-

Base Information

Chemical Name:L-Prolinamide, N-[[[4-(ethoxycarbonyl)phenyl]amino]carbonyl]-L-valyl-N-[3,3,3-trifluoro-2 -hydroxy-1-(1-methylethyl)propyl]-
CAS No.:105108-53-0
Molecular Formula:C₂₆H₃₇F₃N₄O₆
Molecular Weight:558.598
Hs Code.:
Mol file:105108-53-0.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Prolinamide, N-[[[4-(ethoxycarbonyl)phenyl]amino]carbonyl]-L-valyl-N-[3,3,3-trifluoro-2 -hydroxy-1-(1-methylethyl)propyl]-

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Prolinamide, N-[[[4-(ethoxycarbonyl)phenyl]amino]carbonyl]-L-valyl-N-[3,3,3-trifluoro-2 -hydroxy-1-(1-methylethyl)propyl]-

There total 1 articles about L-Prolinamide, N-[[[4-(ethoxycarbonyl)phenyl]amino]carbonyl]-L-valyl-N-[3,3,3-trifluoro-2 -hydroxy-1-(1-methylethyl)propyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid (3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-amide

: 30806-83-8
p-ethoxycarbonylphenyl isocyanate

: 105108-53-0
4-(3-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propyl}-ureido)-benzoic acid ethyl ester

Guidance literature:: In chloroform; for 4h; Yield given; Ambient temperature;
DOI:10.1021/jm960819g

Reference yield:

: 105108-53-0
4-(3-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propyl}-ureido)-benzoic acid ethyl ester

: 105181-51-9
4-(3-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propyl}-ureido)-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) DMSO, oxalyl chloride, 2.) diisopropyl ethylamine / 1.) CH₂Cl₂, -60 deg C, 1 h, 2.) CH₂Cl₂, from -60 deg C to RT

2: 92 percent / 1 N aq. NaOH / methanol / 18 h / Ambient temperature

With sodium hydroxide; oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In methanol;
DOI:10.1021/jm960819g

Reference yield:

: 105108-53-0
4-(3-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propyl}-ureido)-benzoic acid ethyl ester

: (S)-1-{(S)-2-[3-(4-Methanesulfonylaminocarbonyl-phenyl)-ureido]-3-methyl-butyryl}-pyrrolidine-2-carboxylic acid (3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) DMSO, oxalyl chloride, 2.) diisopropyl ethylamine / 1.) CH₂Cl₂, -60 deg C, 1 h, 2.) CH₂Cl₂, from -60 deg C to RT

2: 92 percent / 1 N aq. NaOH / methanol / 18 h / Ambient temperature

3: 60 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran / 18 h / Ambient temperature

With sodium hydroxide; oxalyl dichloride; benzotriazol-1-ol; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;
DOI:10.1021/jm960819g