L-Prolinamide, N-[[[4-(ethoxycarbonyl)phenyl]amino]carbonyl]-L-valyl-N-[3,3,3-trifluoro-1 -(1-methylethyl)-2-oxopropyl]-

Base Information

Chemical Name:L-Prolinamide, N-[[[4-(ethoxycarbonyl)phenyl]amino]carbonyl]-L-valyl-N-[3,3,3-trifluoro-1 -(1-methylethyl)-2-oxopropyl]-
CAS No.:105108-54-1
Molecular Formula:C26H35F3N4O6
Molecular Weight:556.582
Hs Code.:
Mol file:105108-54-1.mol

Synonyms:

Suppliers and Price of L-Prolinamide, N-[[[4-(ethoxycarbonyl)phenyl]amino]carbonyl]-L-valyl-N-[3,3,3-trifluoro-1 -(1-methylethyl)-2-oxopropyl]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Prolinamide, N-[[[4-(ethoxycarbonyl)phenyl]amino]carbonyl]-L-valyl-N-[3,3,3-trifluoro-1 -(1-methylethyl)-2-oxopropyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Prolinamide, N-[[[4-(ethoxycarbonyl)phenyl]amino]carbonyl]-L-valyl-N-[3,3,3-trifluoro-1 -(1-methylethyl)-2-oxopropyl]-

There total 3 articles about L-Prolinamide, N-[[[4-(ethoxycarbonyl)phenyl]amino]carbonyl]-L-valyl-N-[3,3,3-trifluoro-1 -(1-methylethyl)-2-oxopropyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid (3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-amide

: 105108-54-1
4-(3-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propyl}-ureido)-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: CHCl₃ / 4 h / Ambient temperature

2: 1.) DMSO, oxalyl chloride, 2.) diisopropyl ethylamine / 1.) CH₂Cl₂, -60 deg C, 1 h, 2.) CH₂Cl₂, from -60 deg C to RT

With oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In chloroform;
DOI:10.1021/jm960819g

Reference yield:

: 30806-83-8
p-ethoxycarbonylphenyl isocyanate

: 105108-54-1
4-(3-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propyl}-ureido)-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: CHCl₃ / 4 h / Ambient temperature

2: 1.) DMSO, oxalyl chloride, 2.) diisopropyl ethylamine / 1.) CH₂Cl₂, -60 deg C, 1 h, 2.) CH₂Cl₂, from -60 deg C to RT

With oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In chloroform;
DOI:10.1021/jm960819g

Reference yield:

: 105108-53-0
4-(3-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propyl}-ureido)-benzoic acid ethyl ester

: 105108-54-1
4-(3-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propyl}-ureido)-benzoic acid ethyl ester

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; Yield given. Multistep reaction; 1.) CH₂Cl₂, -60 deg C, 1 h, 2.) CH₂Cl₂, from -60 deg C to RT;
DOI:10.1021/jm960819g