6,7-O,O-demethylene-6,7-O,O-dibenzylpodophyllotoxin

Base Information

• Chemical Name: 6,7-O,O-demethylene-6,7-O,O-dibenzylpodophyllotoxin
• CAS No.: 1417534-08-7
• Molecular Formula: C₃₅H₃₄O₈
• Molecular Weight: 582.65
• Mol file: 1417534-08-7.mol

Synonyms:

Chemical Property of 6,7-O,O-demethylene-6,7-O,O-dibenzylpodophyllotoxin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,7-O,O-demethylene-6,7-O,O-dibenzylpodophyllotoxin

There total 2 articles about 6,7-O,O-demethylene-6,7-O,O-dibenzylpodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

6,7-O,O-demethylenepodophyllotoxin (1174-97-6) + benzyl bromide (100-39-0) → 6,7-O,O-demethylene-6,7-O,O-dibenzylpodophyllotoxin (1417534-08-7)

Guidance literature:

With caesium carbonate; potassium iodide; In acetone; at 20 ℃; for 10h;

DOI:10.1021/jf305011n

Reference yield:

podofilox (518-28-5) → 6,7-O,O-demethylene-6,7-O,O-dibenzylpodophyllotoxin (1417534-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1: boron trichloride / dichloromethane / 2.25 h / -70 °C

2: caesium carbonate; potassium iodide / acetone / 10 h / 20 °C

With boron trichloride; caesium carbonate; potassium iodide; In dichloromethane; acetone;

DOI:10.1021/jf305011n

Reference yield: 23.0%

6,7-O,O-demethylene-6,7-O,O-dibenzylpodophyllotoxin (1417534-08-7) + hexanoic acid (142-62-1) → C41H44O9 (1417534-27-0)

Guidance literature:

With dmap; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1021/jf305011n

upstream raw materials:

podofilox

6,7-O,O-demethylenepodophyllotoxin

benzyl bromide

Downstream raw materials:

C₄₁H₄₄O₉

C₄₃H₄₀O₉

C₄₇H₄₂O₉

C₄₂H₃₇NO₁₁