3-((2-methylbenzyl)amino)-4,4-difluoro-5-(4-(pentan-2-yl)-1H-1,2,3-triazol-1-yl)-8-(4-(2-hydroxyacetamido)phenyl)-4-bora-3a,4a-diaza-s-indacene

Base Information

Chemical Name:3-((2-methylbenzyl)amino)-4,4-difluoro-5-(4-(pentan-2-yl)-1H-1,2,3-triazol-1-yl)-8-(4-(2-hydroxyacetamido)phenyl)-4-bora-3a,4a-diaza-s-indacene
CAS No.:1616355-39-5
Molecular Formula:C₃₂H₃₄BF₂N₇O₂
Molecular Weight:597.475
Hs Code.:

3-((2-methylbenzyl)amino)-4,4-difluoro-5-(4-(pentan-2-yl)-1H-1,2,3-triazol-1-yl)-8-(4-(2-hydroxyacetamido)phenyl)-4-bora-3a,4a-diaza-s-indacene

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Chemical Property of 3-((2-methylbenzyl)amino)-4,4-difluoro-5-(4-(pentan-2-yl)-1H-1,2,3-triazol-1-yl)-8-(4-(2-hydroxyacetamido)phenyl)-4-bora-3a,4a-diaza-s-indacene

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Technology Process of 3-((2-methylbenzyl)amino)-4,4-difluoro-5-(4-(pentan-2-yl)-1H-1,2,3-triazol-1-yl)-8-(4-(2-hydroxyacetamido)phenyl)-4-bora-3a,4a-diaza-s-indacene

There total 7 articles about 3-((2-methylbenzyl)amino)-4,4-difluoro-5-(4-(pentan-2-yl)-1H-1,2,3-triazol-1-yl)-8-(4-(2-hydroxyacetamido)phenyl)-4-bora-3a,4a-diaza-s-indacene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616353-18-4
C₃₀H₃₂BF₂N₇

: 13831-31-7
Acetoxyacetyl chloride

: 1616355-39-5,1668597-34-9
3-((2-methylbenzyl)amino)-4,4-difluoro-5-(4-(pentan-2-yl)-1H-1,2,3-triazol-1-yl)-8-(4-(2-hydroxyacetamido)phenyl)-4-bora-3a,4a-diaza-s-indacene

Guidance literature:: C₃₀H₃₂BF₂N₇; Acetoxyacetyl chloride; With sodium hydrogencarbonate; In dichloromethane; at 0 - 20 ℃; for 0.166667h;

With water; potassium carbonate; In methanol; at 20 ℃; for 1h;

Reference yield:

: 3,5-dichloro-8-(4'-nitrophenyl)-4,4-difluoro-4-bora-3α,4α-diaza-s-indacence

: 1616355-39-5,1668597-34-9
3-((2-methylbenzyl)amino)-4,4-difluoro-5-(4-(pentan-2-yl)-1H-1,2,3-triazol-1-yl)-8-(4-(2-hydroxyacetamido)phenyl)-4-bora-3a,4a-diaza-s-indacene

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium azide / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: sodium hydrogencarbonate / dichloromethane / 0.17 h / 0 - 20 °C

2.2: 1 h / 20 °C

With sodium azide; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 143859-77-2
2,2'-[(4-nitrophenyl)methylene]bis(1H-pyrrole)

: 1616355-39-5,1668597-34-9
3-((2-methylbenzyl)amino)-4,4-difluoro-5-(4-(pentan-2-yl)-1H-1,2,3-triazol-1-yl)-8-(4-(2-hydroxyacetamido)phenyl)-4-bora-3a,4a-diaza-s-indacene

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-chloro-succinimide / tetrahydrofuran / 3 h / -78 - 20 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 0 °C

2.2: 2 h / 20 °C

3.1: sodium azide / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 1 h / 20 °C

4.1: sodium hydrogencarbonate / dichloromethane / 0.17 h / 0 - 20 °C

4.2: 1 h / 20 °C

With N-chloro-succinimide; sodium azide; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;