C₄₄H₄₆Cl₆O₁₇

Base Information

• Chemical Name: C₄₄H₄₆Cl₆O₁₇
• CAS No.: 95603-47-7
• Molecular Formula: C₄₄H₄₆Cl₆O₁₇
• Molecular Weight: 1059.56
• Mol file: 95603-47-7.mol

Synonyms:

Chemical Property of C₄₄H₄₆Cl₆O₁₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₄H₄₆Cl₆O₁₇

There total 5 articles about C₄₄H₄₆Cl₆O₁₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

N-chloro-N-sodio-tert-butylcarbamate (73210-14-7) → C44H46Cl6O17 (95603-47-7,95672-97-2) + 7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel (114915-14-9) + C49H55Cl6NO18 (114977-25-2) + C49H55Cl6NO18 (114915-26-3,114977-26-3,114977-27-4)

Guidance literature:

With osmium(VIII) oxide; silver nitrate; In toluene; tert-butyl alcohol; at 4 ℃; for 24h; Further byproducts given; var. solvents and temp.;

DOI:10.1016/S0040-4020(01)81313-2

Reference yield:

7,10-di(2,2,2-trichloroethyloxy-carbonyl)-13-cinnamoyl-10-deacetyl baccatin III (95603-45-5,110281-75-9) → C44H46Cl6O17 (95603-47-7,95672-97-2)

Guidance literature:

With osmium(VIII) oxide; In pyridine; for 1h; Ambient temperature;

DOI:10.1016/S0040-4020(01)87285-9

Reference yield:

10-deacetylbaccatin III (32981-86-5,172018-16-5) → C44H46Cl6O17 (95603-47-7,95672-97-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 153 mg / pyridine / 0.08 h / 80 °C

2: 42 mg / 1.) oxalyl chloride; 2.) silver cyanide / toluene / 20 h / 110 °C

3: 115 mg / osmium tetroxide / pyridine / 1 h / Ambient temperature

With osmium(VIII) oxide; silver cyanide; oxalyl dichloride; In pyridine; toluene;

DOI:10.1016/S0040-4020(01)87285-9

upstream raw materials:

7,10-di(2,2,2-trichloroethyloxy-carbonyl)-13-cinnamoyl-10-deacetyl baccatin III

10-deacetylbaccatin III

(E)-3-phenylacrylic acid

7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III

Downstream raw materials:

13-hydroxy acetyl-10-deacetyl baccatin III

13-<2(R)',3'(S)-dihydroxy-3'-phenyl propanoyl>-10-deacetyl baccatin III

13-<2(S)',3'(R)-dihydroxy-3'-phenyl propanoyl>-10-deacetyl baccatin III

C₃₇H₃₈Cl₆O₁₆