2-(4-trifluoromethylbenzyl)-1-(toluene-4-sulfonyl)-1H-indole

Base Information

• Chemical Name: 2-(4-trifluoromethylbenzyl)-1-(toluene-4-sulfonyl)-1H-indole
• CAS No.: 1379771-52-4
• Molecular Formula: C₂₃H₁₈F₃NO₂S
• Molecular Weight: 429.463
• Mol file: 1379771-52-4.mol

Synonyms:

Chemical Property of 2-(4-trifluoromethylbenzyl)-1-(toluene-4-sulfonyl)-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-trifluoromethylbenzyl)-1-(toluene-4-sulfonyl)-1H-indole

There total 4 articles about 2-(4-trifluoromethylbenzyl)-1-(toluene-4-sulfonyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitro-benzaldehyde (552-89-6) → 2-(4-trifluoromethylbenzyl)-1-(toluene-4-sulfonyl)-1H-indole (1379771-52-4)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere

2: sodium tetrahydroborate; tin(II) chloride hydrate / methanol / 1 h / 0 °C / Inert atmosphere

3: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

4: tetrabutylammomium bromide; potassium carbonate; triphenylphosphine; palladium dichloride / N,N-dimethyl-formamide / 0.08 h / 85 °C / Inert atmosphere

5: palladium 10% on activated carbon; cyclohexene / ethanol / 6 h / Inert atmosphere; Reflux

With pyridine; sodium tetrahydroborate; tin(II) chloride hydrate; palladium 10% on activated carbon; tetrabutylammomium bromide; potassium carbonate; triphenylphosphine; palladium dichloride; cyclohexene; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo300458v

Reference yield:

N-[2-(1-hydroxyprop-2-yn-1-yl)phenyl]-4-methylbenzenesulfonamide (1315477-55-4) → 2-(4-trifluoromethylbenzyl)-1-(toluene-4-sulfonyl)-1H-indole (1379771-52-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; potassium carbonate; triphenylphosphine; palladium dichloride / N,N-dimethyl-formamide / 0.08 h / 85 °C / Inert atmosphere

2: palladium 10% on activated carbon; cyclohexene / ethanol / 6 h / Inert atmosphere; Reflux

With palladium 10% on activated carbon; tetrabutylammomium bromide; potassium carbonate; triphenylphosphine; palladium dichloride; cyclohexene; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jo300458v

Reference yield:

C9H9NO (1379771-04-6) → 2-(4-trifluoromethylbenzyl)-1-(toluene-4-sulfonyl)-1H-indole (1379771-52-4)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: tetrabutylammomium bromide; potassium carbonate; triphenylphosphine; palladium dichloride / N,N-dimethyl-formamide / 0.08 h / 85 °C / Inert atmosphere

3: palladium 10% on activated carbon; cyclohexene / ethanol / 6 h / Inert atmosphere; Reflux

With pyridine; palladium 10% on activated carbon; tetrabutylammomium bromide; potassium carbonate; triphenylphosphine; palladium dichloride; cyclohexene; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo300458v

upstream raw materials:

N-[2-(1-hydroxyprop-2-yn-1-yl)phenyl]-4-methylbenzenesulfonamide

C₉H₉NO

2-nitro-benzaldehyde

α-ethynyl-2-nitrophenylmethanol