Technology Process of Allyl-O-(3,4,6-tri-O-acetyl-2-desoxy-2-phthalimido-β-D-glucopyranosyl)-(1->2)-O-<3,4,6-tri-O-acetyl-2-desoxy-2-phthalimido-β-D-glucopyranosyl)-(1->6)>-3,4-di-O-benzyl-α-D-mannopyranosid
There total 8 articles about Allyl-O-(3,4,6-tri-O-acetyl-2-desoxy-2-phthalimido-β-D-glucopyranosyl)-(1->2)-O-<3,4,6-tri-O-acetyl-2-desoxy-2-phthalimido-β-D-glucopyranosyl)-(1->6)>-3,4-di-O-benzyl-α-D-mannopyranosid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 61 percent / NaH / dimethylformamide / a) -10 deg C, 3 h, b) 0 deg C, 3 h, c) 5 deg C, 4 h
2: 97 percent / 4 A molecular sieves, trimethylsilyltriflate / CH2Cl2 / 1 h / Ambient temperature
3: 87 percent / Bu4NF / various solvent(s) / 12 h / Ambient temperature
4: 100 percent / NaOMe / methanol / 16 h / Ambient temperature
5: 1) 2,4,6-trimethylpyridine, Ag-triflate, 4 Angstroem molecular sieves / 1) CH2Cl2, r.t, 1 h, 2) -10 deg C, 14 h
With
2,4,6-trimethyl-pyridine; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; tetrabutyl ammonium fluoride; sodium methylate; silver trifluoromethanesulfonate; sodium hydride;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0008-6215(92)84169-S
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 98 percent / imidazole / dimethylformamide / 1.5 h / Ambient temperature
2: 61 percent / NaH / dimethylformamide / a) -10 deg C, 3 h, b) 0 deg C, 3 h, c) 5 deg C, 4 h
3: 97 percent / 4 A molecular sieves, trimethylsilyltriflate / CH2Cl2 / 1 h / Ambient temperature
4: 87 percent / Bu4NF / various solvent(s) / 12 h / Ambient temperature
5: 100 percent / NaOMe / methanol / 16 h / Ambient temperature
6: 1) 2,4,6-trimethylpyridine, Ag-triflate, 4 Angstroem molecular sieves / 1) CH2Cl2, r.t, 1 h, 2) -10 deg C, 14 h
With
1H-imidazole; 2,4,6-trimethyl-pyridine; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; tetrabutyl ammonium fluoride; sodium methylate; silver trifluoromethanesulfonate; sodium hydride;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0008-6215(92)84169-S
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 100 percent / NaOMe / methanol / 16 h / Ambient temperature
2: 1) 2,4,6-trimethylpyridine, Ag-triflate, 4 Angstroem molecular sieves / 1) CH2Cl2, r.t, 1 h, 2) -10 deg C, 14 h
With
2,4,6-trimethyl-pyridine; 4 A molecular sieve; sodium methylate; silver trifluoromethanesulfonate;
In
methanol;
DOI:10.1016/0008-6215(92)84169-S
